What is penile burning sensation? Penile burning sensation is a feeling of burning, redness, warmth or swelling in the genitals, particularly in the penis. The sensation can be accompanied by blisters, pain, bloody or pink-colored urine (hematuria), itching, peeling, rash, scabbing, or swelling. Penile burning sensation can be extremely uncomfortable and create difficulty with urination, sexual relations, and daily activities. In addition to symptoms in and around your penis, it can be accompanied by generalized symptoms, such as flu-like symptoms (fatigue, fever, sore throat, headache, cough, aches and pains) and poor health in general. Urethritis is the medical terms for inflammation of the urethra, which is a common cause of penile burning sensation. Cystitis (inflammation of the bladder) or prostatitis (prostate inflammation) can also be associated with a burning sensation in the genitals. Sexually transmitted diseases are examples of infections that can cause penile burning sensation. These diseases include herpes, genital warts (human papillomavirus infection), syphilis (sexually transmitted disease caused by bacteria), chlamydia, or gonorrhea. Men who are uncircumcised (who have the foreskin remaining around the penis) are prone to balanitis, an inflammation of the foreskin most commonly caused by poor hygiene, but which may also be due to infection or irritants. Seek immediate medical care (call 911) if you experience a prolonged, painful erection, the sudden onset of severe testicular pain, if you have redness and tenderness spreading throughout the groin, or if you develop sudden deformity of the penis accompanied by severe pain.