What is dry nose? Dryness of the nose is a common symptom of certain adverse environmental conditions and can also be a side effect of medications. The nose requires a certain level of humidity to work properly, and extremely hot or dry conditions can result in dry nose. Hot, dry climates, low humidity, and air conditioning can all lead to dryness in the nose. Dry nose is a common effect of certain medications, such as some antihistamines and decongestants. Many individuals commonly experience dry nose from the overuse of medications like antihistamines and nasal sprays. Sjogren’s syndrome, an autoimmune disease characterized by dry eyes and mouth, may also result in dry nose. The disease affects the mucous membranes and moisture-secreting glands of the entire body, including the nose. Healthy tear flow drains via the nasal passages. Inadequate tearing caused by Sjogren’s syndrome reduces this source of nasal moisture. Dry nose is rarely a sign of a serious medical condition. Dry nose alone rarely causes serious consequences. Seek immediate medical care (call 911) if dry nose occurs with symptoms of a serious condition such as difficulty breathing or a high fever (higher than 101 degrees Fahrenheit). Seek prompt medical care if your dry nose is persistent or causes you concern.