Natural Immunity vs. Vaccine-Acquired Immunity: Which Is Better?

Medically Reviewed By William C. Lloyd III, MD, FACS
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Is it better to acquire immunity via infection or vaccination?

The human immune system develops the same antibodies in response to, say, chickenpox infection and chickenpox vaccination. People who have had chickenpox and people who received the chickenpox vaccine are well-protected from future infection. In both cases, the body “remembers” and can quickly generate an immune response to attack the chickenpox virus if it’s encountered again, even 20 years after infection or vaccination.

Some people think that natural immunity—developed after infection—is preferable to vaccine-acquired immunity. Both types of immunity (natural and acquired) have pros and cons. Learn more about natural vs. acquired immunity, including what’s known about natural immunity vs. vaccine immunity for COVID-19.

Naturally acquired Immunity 

For some infectious diseases for which there are vaccines, natural infection brings about stronger immunity than the vaccine-acquired immunity. According to the Children’s Hospital of Philadelphia (CHOP), “immunity from disease often follows a single natural infection [but] immunity from vaccines usually occurs only after several doses.” That’s the case with chickenpox—you're usually immune after just one bout of chickenpox, but humans need two doses of chickenpox vaccine to develop effective and long-lasting immunity.

One reason natural immunity is so powerful is because people don’t usually develop illness in response to germ encounters unless they are exposed to a large amount of virus or bacteria. The immune system mounts a strong response to this high “dose” of germs. This powerful response is also responsible for many of the uncomfortable symptoms you feel when you’re sick, such as fatigue, fever and chills.

On the other hand, countless germs, such as human papillomavirus (HPV), evolve to escape detection by the immune system. A healthy immune system eventually clears HPV in 90% of cases, but people who are immunosuppressed are especially vulnerable to long-term infection as well as reinfection.

The biggest downside of natural infection is there’s no way to know, in advance, how serious the infection will be. In most people, chickenpox is an uncomfortable annoyance. But some people also develop a lung infection, swelling of the brain, or life-threatening blood infection. Before chickenpox vaccinations were widely available, approximately 10,000 people in the United States were hospitalized with chickenpox complications each year, and about 100 people died of chickenpox annually.

Vaccine-acquired immunity 

Vaccines stimulate the body to produce the antibodies and memory cells necessary to fight specific infections. The chickenpox vaccine contains tiny amounts of weakened (attenuated) chickenpox virus—enough to cause the immune system to start cranking out antibodies, but not enough for the body to develop chickenpox blisters. The polio and influenza vaccines contain dead (inactivated, or “killed”) viruses; they can’t cause disease, but they kick the immune system into action. COVID-19 mRNA vaccines (and the viral vector vaccine by Johnson & Johnson) teach cells how to make spike proteins like those on the coronavirus, and the body then develops antibodies against those proteins.

Although side effects, such as soreness and fever are common after vaccination, most people don’t feel nearly as lousy after vaccination as they do when they contract an infection.

In some cases, vaccine-acquired immunity is stronger than natural immunity. According to CHOP, HPV, tetanus, Haemophilus influenzae type b (Hib), and pneumococcal vaccines induce a better immune response than natural infection.

Natural vs. vaccine immunity for COVID-19 

Researchers are still learning about natural and vaccine-induced immunity for COVID-19. At present, healthcare providers believe that both COVID-19 infection and COVID-19 vaccination produce immunity that likely lasts at least eight months. This immunity is not complete; it’s possible to contract COVID-19 after COVID-19 vaccination or an earlier bout of infection, though these cases are not usually severe.

Both COVID-19 infection and vaccination trigger production of the specialized immune cells necessary for long-lasting immunity. This type of immunity may not prevent infection or reinfection, but it reduces the likelihood of you developing a severe case of COVID-19.

The exact longevity and strength of immunity in either case is not known yet because COVID-19 is still a new disease. What investigators do know is that COVID-19 vaccination after infection can “sharpen immunity,” which is a good thing. Vaccination after COVID-19 recovery increases production of virus-attacking antibodies and reduces the frequency of reinfection.

What healthcare experts say about natural immunity vs. acquired immunity 

Vaccine-acquired immunity is safer than natural immunity. For all vaccine-preventable illnesses, the risk of developing a serious vaccine-related side effect is much smaller than the risk of serious complications if infected. Anyone who contracts COVID-19 has some level of risk of hospitalization and long-term side effects, including post-COVID-19 syndrome (or “long-haul COVID”), but the risk is greater for some than others. There are known risk factors for severe COVID-19, such as heart disease, but thousands of people with none of those risk factors have developed severe COVID-19. A person who receives the COVID-19 vaccine is unlikely to require hospitalization or develop post-COVID-19 syndrome.

In most cases, healthcare experts recommend vaccination over natural infection, when available. If you have questions about natural and acquired immunity, talk to your healthcare provider.

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Medical Reviewer: William C. Lloyd III, MD, FACS
Last Review Date: 2021 Jul 19
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THIS TOOL DOES NOT PROVIDE MEDICAL ADVICE. It is intended for informational purposes only. It is not a substitute for professional medical advice, diagnosis or treatment. Never ignore professional medical advice in seeking treatment because of something you have read on the site. If you think you may have a medical emergency, immediately call your doctor or dial 911.
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