What Causes Restless Legs Syndrome?

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When you have restless legs syndrome (RLS), one of the questions at the front of your mind is likely: Why? Unfortunately, in most cases doctors don’t know what’s behind the disorder.

Here’s what they do know: In some people, RLS may be due to insufficient levels of iron in the brain or a problem with the brain’s ability to use iron. Normally, the brain uses iron to make the neurotransmitter dopamine. This chemical works in parts of your brain that control your body’s movements. Problems with dopamine can lead to involuntary movements such as those experienced by people with RLS.

Research has found several other factors that can lead to RLS. These include:

Genetics. Having family members with the disorder increases your risk for RLS.

Gender. Women are two times more likely to develop RLS than men. Pregnancy accounts for the difference. Population studies that exclude pregnant women, shows an men and women have an equal likelihood of developing RLS.

Age. While RLS can occur at any age—even children can have RLS—those with more severe cases tend to be middle-aged and older.

Chronic diseases. Certain health problems may affect the levels of iron in your brain or affect the part of the brain that controls body movements and cause RLS. Some examples are:

Pregnancy. Many women experience RLS symptoms during their final trimester. Fortunately, symptoms usually go away within four weeks of giving birth.

Medications. Certain medications used to treat other health issues may lead to RLS. Symptoms usually resolve once you stop taking the medicine. Common culprits include:

  • Antinausea medicines

  • Antidepressants

  • Antipsychotics

  • Cold and allergy medicines with antihistamines

Alcohol, caffeine, and tobacco. Symptoms may improve if you reduce or stop using these substances.

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Medical Reviewer: William C. Lloyd III, MD, FACS
Last Review Date: 2019 Jul 18
THIS TOOL DOES NOT PROVIDE MEDICAL ADVICE. It is intended for informational purposes only. It is not a substitute for professional medical advice, diagnosis or treatment. Never ignore professional medical advice in seeking treatment because of something you have read on the site. If you think you may have a medical emergency, immediately call your doctor or dial 911.

  1. National Heart, Lung, and Blood Institute. http://www.nhlbi.nih.gov/health/dci/Diseases/rls/rls_Causes.html

  2. National Institute of Neurological Disorders and Stroke. http://www.ninds.nih.gov/disorders/restless_legs/detail_restless_legs.htm

  3. Pantaleo NP, Hening WA, Allen RP, Earley CJ. Pregnancy accounts for most of the gender difference in prevalence of familial RLS. Sleep Med 2010; 11:310