The Top 50 Drugs Prescribed in the United States

Medically Reviewed By Alisha D. Sellers, BS Pharmacy, PharmD

Every year, U.S. pharmacies fill billions of outpatient prescriptions. Many of the same drugs have remained in the top 10 spots for several years. These drugs treat some of the most common diseases in the United States, including heart disease and diabetes. Other most commonly prescribed drugs treat:

Here is a list of the top 50 prescription drugs in the United States. This list also includes drugs doctors prescribe that may be available over the counter (OTC). 

Person pouring pills from a prescription bottle into their hand
Raymond Forbes LLC/Stocksy United

1. Atorvastatin

Atorvastatin treats high cholesterol. It is a member of the statins or HMG-CoA reductase inhibitor class. The class has been around for decades. Since 2011, Atorvastatin has been prescribed more than other drugs in its class. The brand name is Lipitor. Total prescriptions: 114,509,814 representing 26,640,141 patients.

2. Levothyroxine

Levothyroxine treats hypothyroidism. It is a synthetic version of the thyroid hormone T4. Brand names include Levothroid, Levoxyl, Synthroid, and Unithroid. Over the past 10 years, levothyroxine has always landed in the top three prescription drugs. Total prescriptions: 98,970,640 representing 20,225,373 patients.

3. Metformin

There are more than 37 million people in the United States with diabetes. So, it is no surprise that metformin — a drug that treats type 2 diabetes — has consistently remained in the top 10 drugs. Brand names include Fortamet, Glucophage, Glumetza, and Riomet. Total prescriptions: 92,591,486 representing 20,122,987 patients.

4. Lisinopril

Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor. Doctors use it to treat high blood pressure, heart failure, and following a heart attack. Brand names include Prinivil and Zestril. It has bumped back and forth between the top four spots over the past 10 years. Total prescriptions: 88,597,017 representing 19,816,361 patients.

5. Amlodipine

Amlodipine is a calcium channel blocker. It treats high blood pressure, coronary artery disease, and angina (chest pain). Since it became a generic drug in the 2000s, it has gained popularity and risen into the top 10 drugs. Norvasc is the original brand name. Total prescriptions: 69,786,684 representing 16,799,810 patients.

6. Metoprolol

Metoprolol is a beta-blocker. Doctors use it to treat high blood pressure, angina, heart failure, and following a heart attack. Metoprolol usage has remained fairly steady over the past decade. Brand names include Lopressor and Toprol XL. Total prescriptions: 66,413,692 representing 15,007,908 patients.

7. Albuterol

Albuterol is an older drug, with commercialization dating to the 1960s. It was also a breakthrough in treating asthma. Today, doctors use it to treat bronchospasm from a variety of lung problems. Its consistent top ranking is a testament to its effectiveness. Brand names include Accuneb, Proair, Proventil, and Ventolin. Total prescriptions: 61,948,347 representing 17,902,020 patients. 

8. Omeprazole

Omeprazole treats heartburn, gastroesophageal reflux disease (GERD), and stomach ulcers. It was the first member of the proton pump inhibitor (PPI) class to gain Food and Drug Administration approval. Its use has increased since it became available OTC. This also decreased the out-of-pocket cost for the drug. The brand name is Prilosec. Total prescriptions: 56,300,064 representing 13,879,629 patients. 

9. Losartan

Losartan is an angiotensin receptor blocker (ARB). Doctors use it to treat high blood pressure, heart failure, and kidney disease in people with diabetes. Losartan broke into the top 50 drugs in 2011 and has been rising since. The brand name is Cozaar. Total prescriptions: 54,815,411 representing 12,690,563 patients.  

10. Gabapentin

Gabapentin falls in the anticonvulsant class of drugs. Along with other medications, it can help control partial seizures in people with epilepsy. It has other neurological uses, including treating nerve pain and restless legs syndrome. Brand names include Horizant and Neurontin. Total prescriptions: 49,961,066 representing 10,571,700 patients.

Other top-selling prescription drugs

The remaining 40 top-selling prescription drugs include: 

  1. Hydrochlorothiazide (Esidrix, Hydrodiuril, Microzide, Oretic), a diuretic to treat high blood pressure and fluid retention. Total prescriptions: 41,476,098 representing 10,031,904 patients
  2. Sertraline (Zoloft), an antidepressant. Total prescriptions: 38,219,814 representing 7,768,366 patients
  3. Simvastatin (Zocor), a statin drug to treat high cholesterol. Total prescriptions: 36,600,871 representing 8,557,525 patients
  4. Montelukast (Singulair), treats asthma and allergies. Total prescriptions: 31,984,479 representing 7,227,021 patients
  5. Escitalopram (Lexapro), an antidepressant. Total prescriptions: 30,605,646 representing 6,342,599 patients
  6. Hydrocodone/acetaminophen (Lortab, Norco, Vicodin, various others), a narcotic analgesic. Total prescriptions: 30,100,356representing 8,587,152 patients
  7. Rosuvastatin (Crestor, Ezallor), a statin drug to treat high cholesterol. Total prescriptions: 29,750,488 representing 7,393,686 patients
  8. Bupropion (Aplenzin, Wellbutrin, Zyban, various others), treats depression and can help with quitting smoking. Total prescriptions: 28,889,368 representing 5,801,282 patients
  9. Furosemide (Lasix), a diuretic to treat high blood pressure and fluid retention. Total prescriptions: 26,786,296 representing 6,405,654 patients
  10. Pantoprazole (Protonix), a PPI for heartburn, GERD, and ulcers. Total prescriptions: 26,604,040 representing 6,814,036 patients
  11. Trazodone (Desyrel, Oleptro), an antidepressant. Total prescriptions: 26,210,731 representing 5,294,364 patients
  12. Dextroamphetamine/amphetamine salts (Adderall), a stimulant for attention deficit hyperactivity disorder (ADHD). Total prescriptions: 26,080,151 representing 3,633,541 patients
  13. Fluticasone (Flonase, Flovent, Cutivate, various others), a corticosteroid. Total prescriptions: 24,777,490 representing 7,805,740 patients
  14. Tamsulosin (Flomax), treats an enlarged prostate. Total prescriptions: 24,692,402 representing 5,856,108 patients
  15. Fluoxetine (Prozac, others), an antidepressant. Total prescriptions: 23,403,050 representing 4,717,183 patients
  16. Carvedilol (Coreg), a beta-blocker. Total prescriptions: 23,159,628 representing 4,948,170 patients
  17. Duloxetine (Cymbalta), an antidepressant. Total prescriptions: 22,546,920 representing 4,461,604 patients
  18. Meloxicam (Mobic), a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation. Total prescriptions: 19,808,581 representing 6,057,630 patients
  19. Clopidogrel (Plavix), prevents blood clots. Total prescriptions: 19,377,527 representing 4,340,688 patients
  20. Prednisone (Deltasone, various others), a corticosteroid. Total prescriptions: 19,044,926 representing 9,203,354 patients
  21. Citalopram (Celexa), an antidepressant. Total prescriptions: 18,549,176 representing 3,683,842 patients
  22. Insulin glargine (Lantus, Toujeo), treats diabetes. Total prescriptions: 17,973,209 representing 3,662,505 patients
  23. Potassium chloride (K-Dur, Klor-Con, Klotrix, Micro-K, Slow-K, various others), a potassium replacement. Total prescriptions: 17,811,732 representing 4,637,643 patients
  24. Pravastatin (Pravachol), a statin drug to treat high cholesterol. Total prescriptions: 17,549,151 representing 4,132,511 patients
  25. Tramadol (Ultram, various others), a narcotic analgesic. Total prescriptions: 17,475,419 representing 4,878,951 patients
  26. Aspirin (various), a pain reliever and anticoagulant. Total prescriptions: 17,287,372 representing 4,741,732 patients
  27. Alprazolam (Xanax), a benzodiazepine used to treat anxiety. Total prescriptions: 16,780,805 representing 3,632,458 patients
  28. Ibuprofen (Advil, Motrin, various others), an NSAID. Total prescriptions: 16,533,209 representing 8,896,328 patients
  29. Cyclobenzaprine (Amrix, Flexeril), a muscle relaxant. Total prescriptions: 16,151,696 representing 5,129,829 patients
  30. Amoxicillin (Amoxil, Polymox, Trimox, various others), an antibiotic. Total prescriptions: 15,922,907 representing 12,780,652 patients
  31. Methylphenidate (Concerta, Metadate, Ritalin, various others), a stimulant for ADHD. Total prescriptions: 15,449,350representing 2,441,634 patients
  32. Allopurinol (Zyloprim), to treat gout and other conditions with high uric acid. Total prescriptions: 15,303,283 representing 3,606,249 patients
  33. Venlafaxine (Effexor, Effexor XR), an antidepressant. Total prescriptions: 15,022,423 representing 2,863,619 patients
  34. Clonazepam (Klonopin), a benzodiazepine. Total prescriptions: 14,758,212 representing 2,498,126 patients
  35. Ethinyl estradiol/norethindrone (various), an oral contraceptive. Total prescriptions: 14,716,809 representing 2,955,082 patients
  36. Ergocalciferol (Drisdol), a vitamin D analog. Total prescriptions: 14,670,983 representing 4,448,964 patients
  37. Zolpidem (Ambien, Edluar, Intermezzo, Zolpimist), a sedative-hypnotic for insomnia. Total prescriptions: 14,272,253 representing 2,592,750 patients
  38. Apixaban (Eliquis), treats and prevents blood clots. Total prescriptions: 13,918,650 representing 3,305,979 patients
  39. Glipizide (Glucotrol), treats diabetes. Total prescriptions: 13,674,142 representing 3,383,057 patients
  40. Lisinopril/hydrochlorothiazide (Prinzide, Zestoretic), a combination ACE inhibitor and diuretic. Total prescriptions: 13,559,563 representing 2,899,536 patients

Where do these drug rankings come from?

These rankings for the most common prescription drugs come from the ClinCalc DrugStats database. This database estimates prescription drug usage from the annual Medical Expenditure Panel Survey (MEPS). 

MEPS is a project of the Agency for Healthcare Research and Quality (AHRQ). It measures how people in the United States use medical care, including prescription drugs. 

AHRQ surveys patients and prescribers to compile this information. Because it is a survey, it includes drugs doctors prescribe that may be available OTC, such as aspirin. 

There is an inherent delay between collecting the data and issuing the DrugStats list. So, the top-selling prescription drugs for the year contain prescriptions from two years prior.


Looking at the top prescription drugs each year can help identify trends. It is also a source for pharmacists and healthcare professionals as they deliver excellent patient care. Many of the same drugs have remained in the top 10 for several years. These treat some of the most common diseases in the United States, including diabetes and heart disease.

Was this helpful?
  1. ClinCalc DrugStats 2021 update – the most commonly prescribed drugs in the United States. (2021).
  2. Drugs, herbs, and supplements.
  3. Statistics about diabetes. (2022).
  4. Top 200 Drugs of 2020.

Medical Reviewer: Alisha D. Sellers, BS Pharmacy, PharmD
Last Review Date: 2022 Sep 29
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