Crohn’s Disease and COVID-19: What to Know

Medically Reviewed By Saurabh Sethi, M.D., MPH
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There is no evidence that Crohn’s disease increases the risk of developing COVID-19. However, taking medications that weaken the immune system may increase the risk of developing severe COVID-19 in people with Crohn’s disease. Getting a COVID-19 vaccination and taking precautions can help protect people with Crohn’s disease.

This article examines the potential risks of having Crohn’s disease and developing COVID-19.

Are people with Crohn’s disease at a higher risk of developing COVID-19?

A woman wearing a face mask
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There is currently no evidence to suggest that Crohn’s disease can increase COVID-19 risk. However, the two conditions may influence each other in other ways.

Treatments for Crohn’s disease often focus on reducing inflammation by controlling an overactive immune response. Specific medications include:

  • Immunomodulators: These drugs suppress the immune system to help the body fight inflammation.
  • Biologic drugs: These are human-made proteins that target specific parts of the immune system that trigger inflammation.

Though these medications can relieve Crohn’s disease symptoms, they might also reduce overall immunity. This, in turn, may affect how the body manages COVID-19 disease.

Research is ongoing to establish the relationship between Crohn’s disease and COVID-19. In the meantime, the Crohn’s and Colitis Foundation recommends that people with IBD continue to take their medications unless their doctor says otherwise.

Learn more about 10 drugs commonly prescribed for Crohn’s disease.

What will happen if someone with Crohn’s disease develops COVID-19? 

COVID-19, like Crohn’s disease, can produce an inflammatory immune response. COVID-19 can also trigger effects that may worsen intestinal inflammation.

In fact, COVID-19 and IBD can sometimes cause overlapping symptoms, such as:

Having inflammatory bowel disease may increase the risk of hospitalization and adverse COVID-19 outcomes. However, further research is needed.

Should people with Crohn’s disease get the COVID-19 vaccine?

According to the World Health Organization (WHO), the COVID-19 vaccine is safe for most people 18 and older with autoimmune disorders.

The Crohn’s and Colitis Foundation also notes that people with IBD react similarly to the COVID-19 vaccination as people in the general population.

Side effects of COVID-19 vaccines 

While COVID-19 vaccines are generally safe and effective, they may cause side effects. These side effects are usually mild, temporary, and can vary from person to person. People with IBD and the general population can all experience side effects.

Side effects may include:

If you have concerns about the safety of the COVID-19 vaccines, discuss them with a healthcare professional. 

Can COVID-19 cause Crohn’s disease?

COVID-19 cannot cause Crohn’s disease. However, COVID-19 may trigger the onset of Crohn’s disease symptoms. This can occur during a case of COVID-19 or after you have recovered. It is unclear why this happens, but the COVID-19 immune response may be involved.

Crohn’s disease is not preventable, but there are steps to protect yourself against COVID-19. Some protective measures include:

  • maintaining adequate ventilation in your surroundings
  • wearing a face mask
  • washing your hands regularly
  • observing physical distancing
  • getting tested if you think you may have been exposed
  • keeping up-to-date on your COVID-19 vaccinations

Learn more about ways to protect yourself from COVID-19.

Other frequently asked questions

Saurabh Sethi, M.D., M.P.H., reviewed the answers to these common questions about Crohn’s disease and COVID-19.

Does Crohn’s disease make you vulnerable to COVID?

There is no evidence that having Crohn’s disease alone can raise your risk of developing COVID-19. However, some of the treatments for Crohn’s disease, like medications that influence the immune system, may increase the risk for severe COVID-19. Further research is needed.

Should people with Crohn’s get the COVID vaccination?

Yes, unless your doctor says otherwise, people with Crohn’s disease and other autoimmune conditions are recommended to get the COVID-19 vaccination. The vaccines are generally safe and effective.


There is no proof that Crohn’s disease can raise the risk of developing COVID-19. However, some IBD drugs may raise the risk of severe COVID-19 in people with Crohn’s disease.

These drugs include immunomodulators and biologic medications. Further research is needed to establish the exact link between IBD and COVID-19 risk.

Talk with your doctor about ways to protect yourself from COVID-19.

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Medical Reviewer: Saurabh Sethi, M.D., MPH
Last Review Date: 2023 Mar 9
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THIS TOOL DOES NOT PROVIDE MEDICAL ADVICE. It is intended for informational purposes only. It is not a substitute for professional medical advice, diagnosis or treatment. Never ignore professional medical advice in seeking treatment because of something you have read on the site. If you think you may have a medical emergency, immediately call your doctor or dial 911.
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