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Controlling Severe Asthma

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Why Is My Asthma Worse at Night? Nighttime Asthma Explained

Medically Reviewed By Nick Villalobos, MD

Experiencing worse asthma at night or around sleep can be common. Inflammatory activity in the body during sleep can cause flare-ups or asthma attacks. Treatment can help manage symptoms and reduce the frequency of flare-ups. Doctors may refer to asthma that is worse at night as nighttime asthma attacks or nocturnal asthma. 

Symptoms of nighttime asthma can include increasing shortness of breath, recurrent wheezing, and waking up with asthma symptoms.

This article explains sleep-related and nighttime asthma attacks, including their symptoms, causes, and triggers. It also discusses treatment and when to contact a doctor.

Symptoms

Someone lies down and sleeps while resting on pillows.
1136143730 yacobchuk/Getty Images

Nighttime asthma is a common presentation of asthma. Research suggests that it may affect 44–61% of people with asthma.

Symptoms of nighttime asthma may include:

  • difficulty breathing
  • shortness of breath
  • wheezing
  • coughing 
  • chest tightness or pressure
  • chest pain
  • waking from sleep with symptoms
  • daytime tiredness or sleepiness

These asthma attacks or flare-ups can be Trusted Source PubMed Central Highly respected database from the National Institutes of Health Go to source a sign that your asthma is more severe. 

If you have nighttime asthma, your respiratory symptoms typically flare up at night or early in the morning.

“Nighttime asthma” can occur at other sleep times

If you have nighttime asthma, your respiratory symptoms typically flare up at night or early in the morning. However, some people may experience worse asthma symptoms any time they sleep, whenever that may be.

For example, people who work at night may sleep during the day. They may then experience sleep-related asthma flare-ups during the day rather than at night.

When to see a doctor

Contact your doctor as soon as possible if you notice gradual or mild worsening of symptoms. This includes more flare-ups at night or around sleep times. This may indicate that your asthma is not responding effectively to treatment.

Severe asthma attacks c Trusted Source PubMed Central Highly respected database from the National Institutes of Health Go to source a Trusted Source PubMed Central Highly respected database from the National Institutes of Health Go to source n Trusted Source PubMed Central Highly respected database from the National Institutes of Health Go to source Trusted Source PubMed Central Highly respected database from the National Institutes of Health Go to source b Trusted Source PubMed Central Highly respected database from the National Institutes of Health Go to source e Trusted Source PubMed Central Highly respected database from the National Institutes of Health Go to source life threatening. Call 911 in any of the following circumstances:

  • symptoms are severe, such as severe chest pain or difficulty breathing
  • symptoms are not improving with quick-relief treatment
  • you do not have access to your quick-relief treatment

Consult your asthma action plan while waiting for care.

Also, contact your doctor if you have concerns or questions about your asthma.

Causes and treatment

An asthmatic reaction or episode begins with Trusted Source PubMed Central Highly respected database from the National Institutes of Health Go to source exposure to a trigger or irritant. This can cause inflammation of the airway, causing obstruction and impairing breathing.

Clinicians are not sure of the exact cause of nighttime or sleep-related asthma attacks. However, there are theories based on research. 

A 2021 review suggests that the following factors may cause asthma to be worse at night or during sleep.

Circadian rhythm

Circadian rhythm is a 24-hour “internal clock” in the brain that regulates Trusted Source National Institute of General Medical Sciences Governmental authority Go to source sleep-wake cycles. Circadian rhythm is a response to light changes in the environment. 

The body’s circadian rhythm may contribute to sleep-related asthma attacks in the following ways:

  • Inflammation: The circadian rhythm can increase immune activity and may cause the release of various inflammatory cells. These cells may increase airway hypersensitivity and airway resistance at night.
  • Hormone levels: The circadian rhythm may stimulate the production of melatonin and other hormones that can contribute to inflammation.

Environmental triggers

Exposure to certain environmental irritants may increase while you sleep or before sleep. If irritants are particularly triggering for you, you may experience worse asthma. Examples include bed sheets containing dust mites, or spending time in smoky areas before sleep.

Other common Trusted Source PubMed Central Highly respected database from the National Institutes of Health Go to source environmental asthma triggers include:

  • other kinds of smoke, vapor, or fragrance
  • cold air, or humid or dry air
  • allergens, such as:
    • animal dander
    • pollen
    • mold
    • cockroaches

Obstructive sleep apnea

Obstructive sleep apnea (OSA) is a disorder that causes the upper airway to become obstructed temporarily during sleep. OSA may affect people with asthma more often than people without.

Symptoms include:

  • abrupt awakening
  • loud snoring
  • severe sleepiness when awake

Treatment

Doctors can often treat OSA with special breathing or oral devices. If needed, your doctor may recommend surgery.

Gastroesophageal reflux disease

Gastroesophageal reflux disease (GERD) is when stomach acid flows backward from the stomach up to the esophagus.

Acid reflux and heartburn due to GERD may be worse in the evening or when lying down. GERD symptoms may affect the nerves of the esophagus, triggering asthma symptoms.

Treatment

Treatment for GERD can include medications such as:

  • antacids
  • H2 blockers
  • proton pump inhibitors

Rhinitis and rhinosinusitis

Rhinitis and rhinosinusitis can both cause inflammation and swelling inside the nose. This leads to nasal pain and congestion.

People with chronic rhinosinusitis and asthma may be more likely to experience nighttime symptoms of asthma.

Also, rhinitis commonly occurs Trusted Source PubMed Central Highly respected database from the National Institutes of Health Go to source at the same time as asthma, and may increase its severity. Rhinitis may worsen at night and in the early morning, further triggering asthma symptoms.

Treatment

Your doctor may recommend:

  • saline nose sprays
  • antihistamine medications
  • decongestants

Additional treatment

Medications for asthma can help reduce inflammation or airway obstruction, and may include Trusted Source PubMed Central Highly respected database from the National Institutes of Health Go to source :

  • inhaled corticosteroids
  • oral corticosteroids
  • long-acting beta-agonists
  • leukotriene-modifying agents

Your doctor may also recommend lifestyle changes, such as quitting smoking or reducing exposure to triggers.

Learn more about medications and treatment for asthma.

For underlying conditions such as GERD or OSA, your doctor can also provide additional specific treatments.

Prevention

You may not be able to prevent all asthma attacks. However, steps to improve asthma that is worse at night may include:

  • sleeping in different positions to help improve breathing or reduce OSA or GERD
  • following your doctor’s treatment advice, including for underlying conditions
  • contacting your doctor if your treatment appears not to be effective, or if you have questions about it
  • avoiding known triggers with actions such as:
    • washing your sheets and cleaning your room regularly to reduce dust mites
    • avoiding sleeping with pets if pet dander triggers your asthma

FAQ

Nick Villalobos, M.D., has also reviewed the following frequently asked questions.

Can you die from an asthma attack in your sleep?

As with any severe asthma attack, asthma attacks during sleep can be life threatening. However, people may wake from sleep during an asthma attack, allowing them to seek treatment and reducing risks.

Does cortisol cause asthma to be worse at night?

Cortisol may cause asthma to be worse at night, in addition to other factors. The circadian rhythm that controls sleep cycles can affect cortisol levels, which, in turn, may contribute to airway obstruction. However, researchers are not yet completely sure about the causes of asthma that is worse at night.

Summary

Experiencing asthma that is worse at night or during sleep can be common. It is unclear why this happens, but the body’s circadian rhythm and conditions such as GERD may be involved.

If you are experiencing worsening symptoms of asthma, doctors may make changes to your treatment plan to improve its effectiveness.

Call 911 for asthma symptoms that are severe or not improving with quick-relief treatment. Also, contact your doctor with any questions or concerns.

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  1. Acid reflux, heartburn, and GERD: What's the difference? (2020). https://magazine.medlineplus.gov/article/acid-reflux-heartburn-and-gerd-whats-the-difference
  2. Antunes, C., et al. (2022). Gastroesophageal reflux disease. https://www.ncbi.nlm.nih.gov/books/NBK441938/
  3. Circadian rhythms. (2022). https://nigms.nih.gov/education/fact-sheets/Pages/circadian-rhythms.aspx
  4. Hashmi, M. F., et al. (2023). Asthma. https://www.ncbi.nlm.nih.gov/books/NBK430901/
  5. Kavanagh, J., et al. (2018). Sleep and asthma. https://journals.lww.com/co-pulmonarymedicine/Abstract/2018/11000/Sleep_and_asthma.7.aspx
  6. Mehra, R. (2014). Understanding nocturnal asthma. The plot thickens. https://ncbi.nlm.nih.gov/pmc/articles/PMC4226043/
  7. Pinyochotiwong, C., et al. (2021). Nocturnal Asthma. http://apjai-journal.org/wp-content/uploads/2021/07/6_AP-231020-0986-1.pdf
  8. Quirt, J., et al. (2018). Asthma. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157154/
  9. Sinyor, B., et al. (2022). Pathophysiology of asthma. https://www.ncbi.nlm.nih.gov/books/NBK551579/
  10. Sleep apnea. (2022). https://www.nhlbi.nih.gov/health/sleep-apnea/causes
  11. Small, P., et al. (2018). Allergic rhinitis. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156899/

Medical Reviewer: Nick Villalobos, MD
Last Review Date: 2023 May 11
View All Controlling Severe Asthma Articles
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