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Controlling Severe Asthma

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Treating Severe Asthma With Prednisone

Medically Reviewed By William C. Lloyd III, MD, FACS

Severe asthma is defined as having ongoing symptoms and complications of the disease despite sticking to proper treatment and regular medication use. People with severe asthma are often prescribed an oral steroid, prednisone, to help manage asthma exacerbations, also known as flare-ups.

Closeup on young woman eating pill

Here are some important things you should know about this asthma medication.    

Why is prednisone used for severe asthma?

During an asthma attack, your airway tissues become inflamed and your airway narrows, leading to coughing, wheezing, and shortness of breath.  Steroids like prednisone reduce the swelling and inflammation by changing the way your immune system responds. This makes it easier for you to breathe.

Prednisone is taken by mouth, either in liquid or tablet form. It is usually given for short periods of time ranging from 3 days to 2 weeks, often called “steroid bursts”. In some cases of hard-to-control asthma, it may be given as a low dose for a longer period of time.

What if I already use a steroid inhaler to treat my severe asthma?

Steroids used to treat asthma can come in different forms. You may have a steroid inhaler that is used once a day as a control medication to help prevent symptoms of asthma from occurring. Also referred to as inhaled corticosteroids, this type of asthma medication acts directly on the tissues of your airway to keep swelling down.

Prednisone, on the other hand, works differently.  It is considered a systemic corticosteroid, meaning its anti-inflammatory action enters the bloodstream and affects your whole body. Other systemic steroids can be given by an injection or into a vein to treat serious asthma attacks that land you in the hospital.

Systemic steroids like prednisone are often used in conjunction with inhaled steroids to manage and treat severe asthma.

What side effects can occur when using prednisone for severe asthma?

When used for short-term treatment, prednisone is generally safe, but does pose the risk of side effects. These side effects can become more serious the higher the dose and the longer you are on the medication.  These include:

  • headache
  • mood changes
  • elevated blood sugar
  • elevated blood pressure
  • fluid retention and weight gain
  • osteoporosis (thinning of your bones)
  • weakened immune system
  • slowed growth
  • elevated pressure within your eyes and cataracts

Be sure to discuss possible side effects with your doctor and notify him or her should any occur.

Are there other things to consider when taking prednisone?

It’s important to take your prednisone just as your doctor orders. Take the correct dose at the correct time, and don’t “double up” if you forget to take a dose. Prednisone may also be given on a tapered schedule, where you slowly decrease the amount you’re taking over time. Stopping prednisone too suddenly can have negative effects on your body, including fatigue, joint pain, and nausea.

Prednisone has the potential to interact with many other medications and natural supplements. This includes medications you purchase over the counter. Let your doctor know about any medications you are taking or before you start something new.

What if I frequently need prednisone to treat my severe asthma?

Many people with severe asthma will be prescribed multiple courses of prednisone, but because of its potential for side effects with long-term use, it’s important to address this with your doctor. Sometimes adjustments can be made in your normal treatment regimen.

You may require higher doses of inhaled corticosteroids or need to be placed on additional control medications to help manage your symptoms.  Ask your doctor about other classes of medications that may be helpful such as:

  • Long-acting beta-adrenergic bronchodilators (LABA): This type of asthma medication can help reduce airway swelling for up to 12 hours.
  • Leukotriene pathway modifiers: These block certain chemicals in the immune system that lead to asthma symptoms.
  • Biologics: These genetically engineered proteins are made from living cells in a laboratory. New biologic treatments are available for certain types of asthma, including allergic and eosinophilic asthma. They can help some cases of severe asthma that previously were hard to treat.

If you have severe asthma, finding the treatment plan that works best for you can be challenging. Prednisone and other steroids can be very effective, especially when you’re recovering from a significant asthma attack, but it may take some fine tuning of your other asthma medications to keep your symptoms at bay. Working closely with your doctor throughout this process can help.

Was this helpful?
  1. A practical guide to the monitoring and management of the complications of systemic corticosteroid therapy. Allergy, Asthma & Clinical Immunology.
  2. Asthma. Cleveland Clinic.
  3. Asthma Medications: Know Your Options. Mayo Clinic.
  4. Corticosteroids in the treatment of acute asthma. Annals of Thoracic Medicine.
  5. Prednisone. Medline Plus.
Medical Reviewer: William C. Lloyd III, MD, FACS
Last Review Date: 2022 Mar 14
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