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Advances in Aortic Stenosis

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The Link Between Diabetes and Aortic Stenosis

Medically Reviewed By William C. Lloyd III, MD, FACS
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Diabetes is a risk factor for aortic stenosis along with smoking, high cholesterol and high blood pressure. What's more, having both diabetes and aortic stenosis makes it more likely that you will develop severe aortic stenosis.

My Aortic Stenosis Confession: Susan

The process that causes aortic stenosis, which is also known as a heart valve failure, is much like the process that causes plaque to build up inside arteries. Diabetes might contribute to this by increasing inflammation and calcium formation. Calcium buildup is the most common cause of aortic stenosis.

What the Research Says

Research studies have made the link between diabetes and aortic stenosis clearer in several areas. For instance:

  • Inflammation. A 2012 study found that people with aortic stenosis who also had diabetes had more inflammation in their aortic valves than if they didn't have diabetes. Those with diabetes also had higher levels of a protein called CRP. CRP levels may rise with diabetes and lead to more inflammation.

  • Severe stenosis. For a 2009 study, researchers gave echocardiograms every so often to people with aortic stenosis. An echocardiogram shows how much narrowing has taken place in the aortic valve. They found severe aortic stenosis developed faster in people with diabetes than in those without diabetes.

  • Heart failure. A 2011 study found that diabetes can make left ventricular hypertrophy (a type of heart enlargement) and heart failure worse in people with aortic stenosis. As aortic stenosis gets worse, the heart has to work harder to force blood out. This causes the left side of the heart to become larger—a condition called left ventricular hypertrophy. Over time, the heart becomes weaker. Blood backs up into the lungs, and not enough oxygen-rich blood goes out to the body, which can result in heart failure. The study looked at tissue samples and measurements taken from the left side of the heart in people having valve replacement surgery. The samples showed that heart failure was worse in people with diabetes. They had more damage to their hearts.

What This Means for You

If you have diabetes, you need to be even more careful about monitoring your aortic stenosis. Talk to your doctor about all your risk factors. And, be sure to tell your doctor about any symptoms you have. These could be:


  • Fatigue after exerting yourself

  • Fainting

  • Chest pain

  • Dizziness

  • Rapid heartbeat

  • Shortness of breath

You may not experience symptoms until the disease progresses to severe aortic stenosis. That’s why it’s extremely important to let your doctor know right away if you have any of these symptoms.

You also need to work even harder to keep your diabetes under control. Aim for these goals:

  • Get your A1C under control (for most people, goal A1C is less than 7 percent). A1C is a measure of how well your blood sugar has been controlled over the last few months.

  • Get your blood pressure under control.

  • Lower your bad cholesterol and raise your good cholesterol by following guidelines from your doctors.

  • Exercise regularly.

  • Maintain a healthy weight.

  • Don't smoke.

  • Limit alcoholic beverages.

  • Eat a heart-healthy diet that's low in salt and saturated fat.

Key Takeaways

  • Diabetes is a risk factor for aortic stenosis. It also may make aortic stenosis worse.

  • Diabetes may contribute to inflammation and the calcium buildup that causes aortic stenosis.

  • If you have diabetes, be sure you know the symptoms of aortic stenosis and talk to your doctor about your risk.

  • If you have diabetes and aortic stenosis, work closely with your doctor to keep your diabetes under the best possible control.

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Medical Reviewer: William C. Lloyd III, MD, FACS
Last Review Date: 2022 Aug 11
View All Advances in Aortic Stenosis Articles
THIS TOOL DOES NOT PROVIDE MEDICAL ADVICE. It is intended for informational purposes only. It is not a substitute for professional medical advice, diagnosis or treatment. Never ignore professional medical advice in seeking treatment because of something you have read on the site. If you think you may have a medical emergency, immediately call your doctor or dial 911.
  1. Diabetes Mellitus Worsens Diastolic Left Ventricular Dysfunction in Aortic Stenosis Through Altered Myocardial Structure and Cardiomyocyte Stiffness, Circulation.
  2. Does Diabetes Accelerate the Progression of Aortic Stenosis through Enhanced Inflammatory Response within Aortic Valves? Inflammation. 
  3. Aortic Stenosis: Diagnosis and Treatment, American Family Physician.
  4. Aortic Stenosis -- Adult, Mount Sinai Hospital.
  5. Does diabetes accelerate progression of calcific aortic stenosis? European Journal of Echocardiography.
  6. Treatment and Prevention of cardiovascular Disease if You have Diabetes, Society for Cardiovascular Angiography and Interventions.