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Dr. O'Connor is a Professor of Medicine and Experimental Therapeutics, and the Director of the Center for Lymphoid Malignancies, and Co-Program Director of the Lymphoid Development and Malignancy Program in the Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center. Over the past two decades, Dr. O'Connor has become an international authority on the management of Hodgkin Lymphoma and non-Hodgkin Lymphoma, as well as the development of novel drugs for the treatment of these diseases. To date, he has pioneered the development of three new drugs approved for the treatment of lymphoma, and collaborated with national and international colleagues on many others. Working in collaboration with the National Cancer Institute (NCI), he was the first to identify the activity of bortezomib (Velcade), a novel class of drugs targeting the proteasome, in patients with relapsed or refractory mantle cell lymphoma, which eventually led to bortezomib becoming the first drug approved by the U.S. Food and Drug Administration for this disease in 2006. He has since developed new treatment regimens integrating bortezomib into the treatment of lymphoma, and conducted the first in human studies of second generation proteasome inhibitors, like carfilzomib. In collaboration with investigators at MSKCC, he conducted the first in human studies of vorinostat, which became the first histone deacetylase inhibitor ever approved for the treatment of cancer in 2005. Vorinostat (Zolinza) was approved in 2005 for the treatment of patients with cutaneous T-cell lymphoma. More recently, he both co-invented and developed pralatrexate (Folytn), which became the first drug ever approved for patients with relapsed or refractory peripheral T-cell lymphoma by the U.S. Food and Drug Administration (FDA) in 2009. Pralatrexate has now been approved for patients in many countries around the world, including Asia. Because of his efforts in developing 2 new drugs approved in T-Cell lymphoma, the Center has developed a unique expertise in treating those rare and complicated diseases, caring for one of the largest populations of T-Cell lymphoma patients in the country. In addition to these drugs, he has recently filed a number of new patents with colleagues at Columbia University on an exciting new class of drugs that target 'master regulators' of cancer cell behavior, which includes NF-kB.& These agents appear active against many cancers including lymphoma, breast cancer and prostate cancer. Presently, Dr. O'Connor is now leading several international studies, many of which are the largest studies ever conducted in various sub-types of lymphoma. His focus is to develop safer drugs that selectively target the unique biology of the cancer cell, all in an effort to minimize the toxic effects of existing chemotherapy treatments. In addition to his efforts in clinical research, Dr. O'Connor runs a laboratory focused on the discovery and development of new drugs for the treatment of lymphoma. His laboratory has developed novel mouse models to accelerate the translation of new discoveries from the laboratory to the clinic. He is widely recognized as an international authority on how to translate novel scientific concepts into patient care.