Dr. Mark Zafereo, MD

Dr. Mark Zafereo, MD

Ear, Nose, and Throat  |  
Male  |  
Age 39
Insurances AcceptedSave
Dr. Mark Zafereo, MD is an ear, nose, and throat doctor who practices in Houston, TX. He is 39 years old and has been practicing for 12 years.

1515 Holcombe Blvd

Houston, TX 77030

Contact Information

Insurance Accepted

  • Aetna
  • Amerigroup (Wellpoint)
  • Assurant Health
  • Blue Cross Blue Shield
  • Blue Cross Blue Shield of Texas
  • Cigna
  • Commercial Insurance Company
  • Government Employees Health Association (GEHA)
  • HAP Insurance
  • 5 More

*Please verify this information when scheduling an appointment.

Learn about Dr. Zafereo

Be confident in your decisions by checking out your provider's top areas of care, education, patient reviews and more. Learn about finding the right doctor for you

Top Care Areas


See how frequently Dr. Zafereo performs your care needs compared to other doctors.

Head and Neck Cancer
very high
more than 99% of peers
Tongue Cancer
very high
more than 97% of peers
Oral Cancer
very high
more than 97% of peers

Dr. Zafereo's percentages are based on the rate of treatment compared to peers nationwide from insurance data. Learn more info about our data and this Top Care Areas component.

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  • Ear, Nose, and Throat
  • Oncology

Board Certifications

  • Otolaryngology
    Accredited by: American Board of Otolaryngology*

Conditions Treated

  • Acute Upper Respiratory Infection
  • Adolescent Cancer
  • All Headaches (incl. Migraine)
  • All Lymphoma
  • Allergic Reaction
  • Anal Disorders
  • Anal and Rectal Cancer
  • Autoimmune Diseases
  • Basal Cell Carcinoma
  • Bladder Cancer
  • Bleeding Disorders
  • Blood Disorders
  • Bone Cancer
  • Bone Disorders
  • Brain Cancer
  • Brain Disorders
  • Brain and Nervous System Cancer (incl. Gliomas, Astrocytoma, Schwannoma, Medulloblastoma, Chordoma)
  • Breast Diseases
  • Burkitt's Lymphoma
  • Cancer
  • Carcinoma in Situ
  • Central Nervous System Lymphoma
  • Chronic Myeloid Leukemia (CML)
  • Colorectal Cancer
  • Conductive Hearing Loss
  • Cough
  • Deformities of Auricle or Pinna
  • Dizziness
  • Drooping Eyelids (Ptosis)
  • Dysphagia
  • Ear Ache
  • Ear Cancer
  • Ear Disorders
  • Earwax Buildup
  • Endocrine Cancer
  • Esophageal Cancer
  • Esophageal Diseases
  • Eustachian Tube Dysfunction
  • Eyelid Disorders
  • Follicular Thyroid Cancer
  • Fracture
  • Gastrointestinal Diseases
  • Geographic Tongue
  • Gland Cancer
  • Gum Cancer
  • Head and Neck Cancer
  • Head or Neck Lump or Swelling
  • Hoarse Voice (Dysphonia)
  • Hypercoagulable State
  • Laryngeal Cancer
  • Larynx Conditions
  • Leukocytosis
  • Leukoplakia
  • Lip Cancer
  • Lymphoma, Large Cell, Anaplastic
  • Lymphosarcoma
  • Malignant Bone Cancer of the Skull, Face, and Jaw
  • Marginal Zone Lymphoma
  • Mediastinal Tumors, Malignant
  • Medullary Thyroid Cancer
  • Melanoma
  • Meniere's Disease
  • Merkel Cell Carcinoma
  • Metastatic Cancer
  • Multiple Myeloma
  • Mycosis Fungoides
  • Myelodysplastic Syndromes
  • Myeloproliferative Disorders
  • Nasal Cavity Cancer
  • Neck Cancer
  • Nerve Cancer
  • Neuroendocrine Tumors
  • Nose Cancer
  • Nosebleed
  • Oral Cancer
  • Osteosarcoma
  • Outer Ear Infection
  • Pancytopenia
  • Papillary Thyroid Cancer
  • Parathyroid (Gland) Tumor: Other than Malignant
  • Parathyroid Cancer
  • Pediatric Cancer
  • Perforated Eardrum
  • Peripheral T-Cell Lymphoma
  • Pharyngeal Cancer
  • Pharyngitis
  • Pleura Cancer
  • Postnasal Drip
  • Primary Central Nervous System Lymphoma
  • Primary Hypercoagulable State (incl. Factor V Leiden Disease)
  • Pulmonary Disease
  • Reticulosarcoma
  • Retina Diseases
  • Salivary Gland Cancer
  • Secondary Hypertension
  • Secondary Malignancies
  • Sinus Cancer
  • Skin Cancer
  • Sleep Disorders
  • Soft Tissue Sarcoma
  • Soft Tissue Sarcoma of Head, Face, and Neck
  • Sore Throat
  • Squamous Cell Carcinoma
  • Stomach Cancer
  • Stomach Diseases
  • Stomach and Small Intestine Cancer
  • Throat Cancer
  • Throat Cancer (Hypopharyngeal)
  • Throat Cancer (Nasopharyngeal)
  • Throat Cancer (Oropharyngeal)
  • Thrombocytosis
  • Thyroid Cancer
  • Thyroid Cancer, Anaplastic
  • Thyroid Cancer, Familial Medullary
  • Thyroid Cancer, Hurthle Cell
  • Tongue Cancer
  • Tonsil Cancer
  • Trachea Cancer
  • Trigeminal Neuralgia
  • Urinary Disorders
  • Vascular Disease
  • Vertigo
  • Vocal Cord Carcinoma
  • Vocal Cord Nodule
  • Vocal Cord Paralysis
  • Vocal Cord Polyp
  • Wheezing


Read More


  • Abscess or Cyst Drainage or Aspiration
  • Abscess or Fluid Incision and Drainage
  • Cervical Lymph Node Dissection
  • Continuous Positive Airway Pressure (CPAP)
  • Diagnostic Nasal and-or Sinus Endoscopy
  • ENT Surgery
  • Ear Surgery
  • Ear Tube Placement
  • Excision of Facial Bone
  • Excision of Parotid, Sublingual, or Submandibular Gland
  • Excision of Tracheal Tumor or Stenosis
  • Excision or Destruction of Dentoalveolar Lesion or Tumor
  • Excision or Destruction of Palate or Uvula Lesion
  • Excision or Destruction of Pharynx Lesion
  • Excision or Destruction of Tongue Lesion
  • Glossectomy
  • Head and Neck Surgery
  • Intranasal or Sinus Procedure
  • Laryngectomy and Pharyngectomy
  • Laryngoscopy - Laryngotomy - Laryngectomy - Pharyngolaryngectomy - Pharyngectomy
  • Laryngoscopy and Laryngotomy
  • Lip, Excision or Resection
  • Lymph Node Biopsy or Excision
  • Nasal Septum Surgery (Septoplasty)
  • Parathyroid Surgery
  • Parathyroidectomy
  • Sinus Surgery
  • Thyroid Lobectomy
  • Thyroidectomy
  • Thyroidectomy or Thyroid Lobectomy
  • Tonsillectomy
  • Tracheal Surgery
  • Vestibule and Floor of Mouth, Excision or Destruction
  • Wound Repair


Read More

Background Check

0 Malpractice Claims

No malpractice history found for Texas.

0 Sanctions

No sanctions history found for the years that Healthgrades collects data.

0 Board Actions

No board actions found for the years that Healthgrades collects data.


  • University Of Texas / Austin Campus
    Undergraduate School | Graduated 2001
  • U Of Tx Med Sch At Houston
    Medical School | Graduated 2005
  • University Of Texas At Houston / Medical School At Houston
    Internship Hospital | Completed 2006
  • Baylor University
    Residency Hospital | Completed 2010
  • University Of Texas At Houston / Medical School At Houston
    Residency Hospital | Completed 2007
  • MD Anderson Cancer Ctr Houston
    Fellowship Hospital | Completed 2011

Awards & Recognition

Awards & Honors
  • Healthgrades Honor Roll
Media & Publications

Dr. Zafereo has no media or publications listed.

Languages Spoken

  • English

Memberships & Professional Affiliations

Dr. Zafereo does not have any memberships or affiliations listed. If you are Dr. Zafereo and would like to add memberships or affiliations, please update your profile.

Dr. Zafereo's Reviews

Likelihood of recommending Dr. Zafereo to family and friends
based on 87 total reviews (31 with comments)
Dr. Zafereo's Performance
  • Trustworthiness
  • Explains condition(s) well
  • Answers Questions
  • Time well spent
Office & Staff Performance
  • Scheduling
  • Office environment
  • Staff friendliness
  • Average wait time
    10 to 15 minutes
Patient Comments (31)
katy, TX |
To my experience, Dr. Zafereo is excellent in his field as well as making patients feel comfortable. When i met him, i was so much concerned and afraid of my cancer but the way he spoke to me, guided me through the treatment process, answered my questions/concerns/doubts, i was so relaxed coming out of consultation room. He is a great person with great skills.
Dr. Zafereo is patient to his patient and is confident in his expertise. He visited me and checked my condition after a long surgery on the same day of my surgery. I am grateful to have Dr. Zafereo as my surgeon.
in Tuscaloosa |
Dr. Zafereo and his staff are so amazing. He saved my brother Devon life. I cannot thank you enough. You guys treated us like family. Dr Zafereo you are gods gift to this world and I pray that he continue to bless you and guide your hands daily to saving more lives. Again thank you ...thank you...thank you.
in Clanton, AL |
I don't have words to explain how much I thank and respect Dr. Mark Zafereo for saving my life..he makes my 8 hrs surgery feels like I was on a 8 days vacation. He personally called me weeks after leaving the hospital to check on my recovery..I never had a Doctor to personally check on me before.. He is more than a Doctor, he's a true man of God, a family member and a friend. I RECOMMEND DR. ZAFERO FOR YOUR MEDICAL NEEDS. THE BEST DR. ON EARTH. THANK YOU MY DOCTOR AND MY NEE FRIEND..Dr. Mark.
in Owasso, OK |
I am so pleased and feel very fortunate that I have Dr.Zafereo as my Dr. at MD Anderson, very professional, understanding and answers your questions . I would highly recommend Dr. Zafereo.
Dr. Zafereo is a knowledgable surgeon who gives attention to each patient as a individual. He has a passion for what he does! He is also very nurturing towards his patients and family.
in Sugar Land, TX |
He and his colleagues are the Best!!
in Missouri City, TX |
Dr. Zafereo is amazing! He truly cares for each of his patients. He has a gentle bedside manner. I was confident that I was in good hands in a seemingly impossible medical situation. Dr. Zafereo developed a successful treatment plan for my care. I am celebrating three years as a head and neck cancer survivor. My diagnosis was Mucoepidermoid Carcinoma of the parotid gland. My tumor was aggressive and required a complex medical plan. I trusted Dr. Zafereo's knowledge and skill. I recommend him.
Beaumont, TX |
I was very impressed with his professionalism. He was very pleasant and knowledgeable.
in Covington, LA |
I highly recommend Dr. Mark Zafereo to anyone in need of his surgical speciality. He is exceptional.
Baton Rouge, LA |
Dr Zafereo was the surgeon for my parathyroid re-do surgery. His followup, skill and knowledge as well as his manner of communication were fabulous. Highly recommend.
I was given several options for head and neck surgeons at MD Anderson to remove a cancerous thyroid lobe and I chose Dr. Zafereo since he was head of that section. The surgery was uneventful; my family and I were very impressed with him and his staff. I suggest that future patients consider Dr. Zafereo for their thyroid surgery.
Houston, TX |
My experience with Dr. Zafereo was extremely pleasant. He not only explained the plan of action for my treatment but was very thoughtful and caring about keeping my family informed on what was to be expected with my surgery and post-op. I highly recommend him to anyone seeking or needing neck surgery.
Valencia, CA |
My mom is a thyroid cancer patient of Dr Zafereo's. He is a exceptional surgeon with a very compassionate disposition. I would highly recommend him and his wonderful staff. He definitely went above and beyond for our family. We truly appreciate the excellent care and attention that was given to our Mom. Thanks Dr. Zafereo and staff!!!!
in Round Rock, TX |
Dr. Zafereo is truly in a league of his own. It has been a week and a half since my total thyroidectomy and neck dissection and I am practically 100% back to my normal self. This is all thanks to Dr. Zafereo and his amazing team. Dr. Zafereo has a calming presence that will make you feel at ease knowing you are in the best possible hands, no matter how dire your situation. If I ever have a loved one who needs ENT surgery, Dr. Zafereo is the only choice, he is simply the best. 10/10.
in Hurst, TX |
Dr. Zafereo is absolutely the best! I feel so fortunate to have him as my surgeon! His skill level is phenomenal!
in Los Alamos |
After meeting Dr. Zafereo in the office and spending nearly 45 minutes discussing my condition, procedure options, side effects of the final treatment decision, surgery, recovery, etc, I had total confidence in him and his staff. Anyone at MD Anderson I spoke to that knew Dr. Z said he was the best in the world. The skills and knowledge he has are amazing. He is the absolute best. And great bedside manner, caring and thoughtful.
in Houston, TX |
Dr. Zafereo has good bedside manners and has excellent patience. I would recommend him to my family and friends. He is very knowledgeable about his specialty. He doesn't rush when speaking to you and he definitely doesn't push his assistant on you. That's what I love about him. When I go for my appointment I see him and not the assistant.
in Dothan, AL |
Dr. Zafereo is a competent physician. He has such good bed side manners. He gave me the information I need to make an informed decision. He gave me his honest opinion which I trust. He is a blessing from God.
Houston, TX |
Dr Zafereo was very patient with me and made me feel comfortable. I would recommend his to anyone. He is caring, trusting and a great surgeon.
in Houston, TX |
Dr. Zafaero did a great job with my thyroidectomy. He was very knowledgeable, compassionate, and professional. I am happy to have a good doctor during a difficult time in my life. MD Anderson also was a great hospital: very organized and professional.
in Puerto Rico |
Dr. Zafareo took care of my mother's metastised thyroid cancer and very professionally did an outstanding job. Not only he did a great job with her surgery and follow up, but he also has an excellent personality which his patients love. He treats his patients and families with dignity, respect and compassion. He rounds on his patients and keeps his promises to them even if he has to round late at night. He is a very unique physician with many beautiful attributes which serve him well.
in El Campo, TX |
Dr. Zafereo is GREAT! Not only is he a excellent surgeon but he is one of the most compassion caring doctors that you could ever ask for!
in Houston, TX |
Waited a long time in sugarland office when doctor was not even there.
in Sugar Land, TX |
I would HIGHLY recommend Dr. Zafereo for any medical/surgical needs. He is not only very knowledgeable, but SO pleasant and compassionate which is very important when you are posed with life altering decisions. You can tell by the look in his eyes that he truly cares about your health and the impact his gifted hands will have on the outcome. He was highly recommended to me, and I am grateful for that. May God continue to bless him as he blesses others with his gifted skills and kind heart.
in Richmond, TX |
Dr. Zafereo is not only a very knowledgeable and highly-skilled surgeon, he is also very patient and takes the time to explain procedures, expected results, and aftercare in a manner that is easily understood. Dr. Zafereo is not only one of our favorite doctors; he is one of our favorite persons. He is kind, compassionate, and dedicated to the care of his patients and to his profession. We are amazed at the number of people we have met who feel the same way we do about Dr. Zafereo!
in Raymondville, TX |
I would recommend Dr. Zafereo to anyone who wants to be cared for by a physician who is competent, kind-hearted, and compassionate. He listens to his patients questions and concerns with an open mind and delivers his responses in a manner that you understand so that you may make an informed decision regarding your care. MD Anderson is heaven on earth and Dr. Zafereo is a great angel in this heaven..he saved my life and my family and I are forever grateful! :-)
in Houston, TX |
Dr. Zafereo was absolutely amazing. He made me feel comfortable and at ease, he held my hand when he saw the frightened look on my face, he was so comforting and made my surgery an extremely positive experience.. Absolutely the best surgeon I could have had.
in Harlingen, Tx. |
He was very kind and an all around awesome person!
in Cancun, Mexico |
Dr. Zafereo is an outstanding surgeon who treats his patients with respect and and a genuine friendliness that is sometimes lacking in other doctors. It is obvious that he has a tremendous workload, but he always has time to stop and have a friendly chat with his patients. I am very pleased that Dr. Zefereo is my treating physician. His staff is as equally professional as well as compassionate.
He really cares
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Now Accepting New Patients
Dr. Zafereo accepts 14 insurance carriers
  • Aetna
    Aetna HMO
    Choice Plus POS II
  • Amerigroup (Wellpoint)
  • Assurant Health
  • Blue Cross Blue Shield
    Blue Card PPO
  • Blue Cross Blue Shield of Texas
    Blue Choice
  • Cigna
    Cigna HMO
    Cigna PPO
    Open Access
  • Commercial Insurance Company
  • Government Employees Health Association (GEHA)
  • HAP Insurance
    Health Alliance
  • Humana
    Choice Care PPO
  • Medicaid
  • MultiPlan
    MultiPlan PPO
    PHCS Network PPO
  • National Elevator
  • UnitedHealthCare
    Choice Plus POS
    Navigate HMO
    Navigate POS
    Options PPO
    United Healthcare

*Please verify this information when scheduling an appointment.

Hospitals where Dr. Zafereo has admitting privileges

Houston Methodist Sugar Land Hospital
16655 Southwest Fwy
Sugar Land, TX 77479
View Hospital Profile
St. Luke's Sugar Land Hospital
1317 Lake Pointe Pkwy
Sugar Land, TX 77478
View Hospital Profile
The University of Texas M.D. Anderson Cancer Center
1515 Holcombe Blvd
Houston, TX 77030
View Hospital Profile

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