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Joseph A. Califano, III, MD, is a board-certified otolaryngologist. He is an internationally recognized head and neck surgeon who specializes in tumors of the oral cavity (mouth), salivary glands, pharynx (throat), larynx (voice box), sinuses, thyroid, and skull base. Dr. Califano has expertise in minimally invasive surgical techniques, including endoscopic laser and robotic surgery, to help best preserve function and appearance in his patients. He has an interest in HPV-related cancers of the throat, as well as premalignant conditions of the upper aerodigestive tract. Dr. Califano is a professor and vice chief of the Division of Otolaryngology at UC San Diego School of Medicine’s Department of Surgery. His research focuses on the molecular biologic basis of head and neck cancer development. Dr. Califano also leads clinical trials investigating the use of Cialis to modulate immune suppression in head and neck cancer. His other areas of investigation include integrative network-based molecular analysis of head and neck tumors; detection of recurrent and occult primary cancer within blood and saliva using molecular biologic techniques; and defining the underlying biology of head and neck cancers. A frequent speaker at national and international meetings, Dr. Califano has coauthored numerous textbooks and book chapters and over 230 peer-reviewed articles related to both clinical and scientific aspects of cancer. His work has appeared in Nature, Oral Oncology and Clinical Cancer Research, among others. He reviews and serves on the editorial board for a variety of medical journals, including Oral Oncology, the most respected specialty journal in head and neck cancer. Prior to joining UC San Diego Health in 2015, Dr. Califano was a professor in the Department of Otolaryngology - Head and Neck Surgery at Johns Hopkins School of Medicine in Baltimore. He also served as the medical director of Milton J. Dance, Jr. Head and Neck Cancer Center at Greater Baltimore Medical Center. Dr. Califano completed a fellowship in the Department of Surgery at Memorial Sloan Kettering Cancer Center and a residency in otolaryngology – head and neck surgery at Johns Hopkins Hospital. He earned his medical degree from Harvard Medical School. Dr. Califano is board-certified in otolaryngology. He is a fellow of the American College of Surgeons and member of numerous professional organizations, including the American Association for Cancer Research, the American Academy of Otolaryngology Head and Neck Surgery and the American Head and Neck Society. He is also a founding fellow and councilor of the International Academy of Oral Oncology. An active member of these organizations, Dr. Califano has served on committees for several of the societies. He is consistently elected as a top physician in the annual survey for Castle Connolly’s America's Top Doctors® for Cancer.In his free time, Dr. Califano enjoys rock climbing, and is learning how to surf. He and his wife, Beth, have two children.