Dr. John DeSantis, DO

Orthopedic Surgery  |  
Male  |  
Age 64
Insurances AcceptedSave
Dr. John DeSantis, DO
John G. DeSantis, D. O., is a board certified fellowship-trained orthopedic surgeon specializing in total hip and total knee reconstruction. A native of Michigan, Dr. DeSantis moved to Southern California to join Desert Orthopedic Center in 2008. Prior to moving to Rancho Mirage, Dr. DeSantis practiced in Michigan where he had established the Knee and Orthopedic Center in 1988 after completion of his fellowship in Florida. Dr. DeSantis has successfully performed thousands of hip and knee surgeries including arthroscopic knee surgery, total hip replacement and hip resurfacing, total knee and partial knee replacement, custom knee replacement, revision hip and revision knee replacement, bilateral knee replacement and combined hip and knee replacement surgery. Dr. DeSantis performs hip surgeries through the "bikini incision" anterior approach. The biggest advantage for his patients is that this allows immediate freedom in their hip range of motion and early return to their desired activities. He prefers this approach as patients are not required to follow traditional hip precautions which limit hip flexion and range of motion postoperatively. Dr. DeSantis graduated from Michigan State University College of Osteopathic Medicine and completed an orthopedic residency at Detroit Osteopathic/Bi County Community Hospital in Michigan. He is a Diplomat of the National Board of Examiners and has served as an oral examiner for the AOA Orthopedic Certification Examination. He is a member of the American Medical Association, the American Osteopathic Academy of Orthopedics, American Osteopathic Association, the American Osteopathic Academy of Sports Medicine and the American Association of Hip and Knee Surgeons.

39000 Bob Hope Dr

Rancho Mirage, CA 92270

Contact Information

(760) 568-2684

Dr. John DeSantis, DO

Dr. John DeSantis, DO

Accepted insurance

  • Accepts most major Health Plans. Please contact our office for details.

*Please verify this information when scheduling an appointment.

Learn about Dr. DeSantis

Be confident in your decisions by checking out your provider's top areas of care, education, patient reviews and more. Learn about finding the right doctor for you

Top Care Areas


See how frequently Dr. DeSantis performs your care needs compared to other doctors.

Knee Replacement
very high
more than 93% of peers
Hip Replacement
more than 81% of peers
Arthritis of the Elbow
more than 5% of peers

Dr. DeSantis's percentages are based on the rate of treatment compared to peers nationwide from insurance data. Learn more info about our data and this Top Care Areas component.

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Care Philosophy

This content was provided by Dr. DeSantis ""The most rewarding part of hip and knee reconstruction is hearing from patients how happy they are that they can get back to activities they once enjoyed""


  • Orthopedic Surgery
  • Joint Replacement Orthopedic Surgery

Board Certifications

  • Orthopedic Surgery
    Accredited by: American Osteopathic Board of Orthopedic Surgery*

Conditions Treated

  • Ankle and Foot Instability or Derangement
  • Arthritis of the Elbow
  • Ataxia
  • Bone Cancer
  • Broken Neck
  • Hip Pain
  • Knee Pain
  • Lumbar Spine Fracture
  • Morton's Neuroma
  • Nerve Root Injury and Plexus Disorders (incl. Pinched Nerve)
  • Osteoarthritis of Hands


  • Ankle Replacement
  • Hip Replacement
  • Joint Replacement Surgery
  • Knee Replacement
  • Separated Femoral Epiphysis Treatment

Background Check

0 Malpractice Claims

No malpractice history found for California.

0 Sanctions

No sanctions history found for the years that Healthgrades collects data.

0 Board Actions

No board actions found for the years that Healthgrades collects data.


  • Central Michigan University
    Undergraduate School | Graduated 1977
  • Michigan State University / College Of Osteopathic Medicine
    Medical School | Graduated 1980
  • Detroit Osteopath/Bicounty Hosps
    Internship Hospital | Completed 1981
  • Detroit Osteopathic Hospital
    Residency Hospital | Completed 1986
  • The Florida Knee Center
    Fellowship Hospital | Completed 1988

Awards & Recognition

Awards & Honors
  • Healthgrades Honor Roll
Media & Publications

Dr. DeSantis has no media or publications listed.

Languages Spoken

  • English

Memberships & Professional Affiliations

  • California Orthopedic Association, Member

Dr. DeSantis' Reviews

Likelihood of recommending Dr. DeSantis to family and friends
based on 65 total reviews (39 with comments)
Dr. DeSantis' Performance
  • Trustworthiness
  • Explains condition(s) well
  • Answers Questions
  • Time well spent
Office & Staff Performance
  • Scheduling
  • Office environment
  • Staff friendliness
  • Average wait time
    10 to 15 minutes
Patient Comments (39)
in La Quinta, CA |
I had bi-lateral knee replacement in July 2017 by Dr. DeSantis. I had been having gel injections for 2 years and needed both knees replaced. Thank goodness he was willing to do both at one time. I certainly did not want to go through surgery twice. He was professional and to the point. I am now 9 weeks after surgery and doing quite well
in YPalm Desert, CA |
Excellent Doctor and staff. TKR revision(he had to fix another surgery, from another state). From start to finish, I was heard, tested and given options. He is skilled, confident and caring. Thank you Dr. You have helped me reclaim my life! Start to finish, no complaints from me! Highly recommend.
in La Quinta, CA |
I have been seen by Dr. DeSantis since April of 2017, for a work related knee injury. Dr. Desantis has been, by far, one of very best doctors I have ever dealt with. He is extremely experienced in his field, and his contact with patients is outstanding. He carefully explains options and his recommendations are based on a very strong "Patient Care First" position. His staff at DOC are all top tier, and work hard to ease patients through their visits. I say a solid 100% in all service areas.
in Thousand Palm, CA |
Dr. DeSantis performed a bi-lateral knee replacement. From the first day starting with the scheduling department to my first post opt appointment everything has been perfect. I am in week 6 now and have great bending motion on both knees. I have been very satisfied with the results and would recommend bi-lateral knee replacements for everyone if you have the need to do both. I am very pleased with the surgery and feel I chose the right doctor for the job.
in La Quinta, CA |
I had total left hip replacement surgery on June 28, 2017. Dr. Desantis and his staff did a great job. I had my one month follow up appointment today and was quickly taken to get a new x-ray for the doctor to review the progress of the implant. Upon return to the consultation room, I was greeted by Dr. Desantis who reviewed my x-ray with me and provided guidance and direction for my ongoing recovery. He took the time to answer all of my questions and was genuinely interested in my condition.
in Palm Springs, CA |
As a recently retired R.N. needing double hip replacement surgery for osteoarthritis, I am happy I found Dr. DeSantis. I researched orthopedic surgeons in the Palm Springs area and learned he uses the anterior approach with a small incision. Meeting Dr. DeSantis sealed the decision for me: he was willing to operate on both hips at the same time; he is approachable, communicative, warm and very competent. I am eight weeks post-op, walking and driving without aid, fully enjoy retirement.
in Cathedral City, CA |
Yesterday, I had my last Post Op visit, with Dr DeSantisn, after a total hip replacement. Dr. DeSantis is a God. He is the giver of life for me. I can't say enough about him, his staff, and the staff at EMC. Dr. DeSantis went above and beyond what was required. My first visit he looked at the X Ray and told me that I needed a total hip replacement and I was scheduled for surgery the following Monday. Who does that? Dr. DeSantis, that's who. Thank you Sir, Jeff Byrd
in Indio, CA |
Dr. DeSantis is an EXCELLENT Orthopedic Surgeon. I am in my 80's, I had complete hip replacement. He listened to my questions and concerns and did not interrupt me. His staff were always polite. Rhonda always returned my calls. He is a 5 STAR Doctor.
in Indio, CA |
A year ago Dr. DeSantis Performed a total left hip replacement. I have been pain free, can sleep comfortably, walk normally and improved my quality of life. I owe it all to him.
in CA |
I had a total hip replacement in 2011 and a review of. The same hip in 2016. 2 days after my surgery I was shopping for my daughter's wedding. I haven't had any pain or discomfort. Dr. DeSantis is a genius, very compasionate and with great professional ethics. I highly recommend Dr. DeSantis.
in Rancho Mirage, CA |
Three months ago, Dr. DeSantis performed 100% knee replacement for me and nine weeks later I was playing golf. I could not be happier with Dr. DeSantis and his staff. In general, Eisenhower Medical Center did a wonderful job. The one key area they fell short on was pain control as they did not have the ability to control my pain for 44 hours.
in Burbank, CA |
desantis beyond incompetent. . 3 years not being able to sit since replaced. One doc says back, back says knees. Oct they do a CT Scan. Now I have bone spurs above and below my knee caps. Now no question knee. DeSantis walks in goes to look at Xray. I am trying to give history. He turns says your knees are fine. I was shocked he had not touched my knees, not even looked at CT Scan. Then he says I can't do anything for me. Kept repeating it. Walks Out of the room. Less than 5 minutes. Unreal.
in Palm Desert, CA |
Worst oath doctor in the valley. Contacted MRSA following hip surgery,maybe surgery maybe skilled nursing. Two subsequent surgeries still infected, went to another specialist and now I am healthy again. His PA is totally worthless,went to see him with open wound dripping infection and he did an X-ray and sent me home. Worst PA I have ever dealt with,license should be yanked fro uncaring attitude and negligent care.
La Quinta, CA |
Unprofessional, disrespectful, devoid of compassion!
in Indio, CA |
Excellent service very personable my knee replacement was awesome
in Whitewater, Ca. |
He is a superb surgeon with excellent aftercare practices. Bedside manner a little abrupt but not uncommon for surgeons with his level of skill. I had bilateral knee replacement and reccomend him highly.
in Yucca Valley, CA |
Dr. De Santis restored my quality of life through his superior ability to perform restorative full knee replacement (s) surgery assisted by a more than competent surgical team and the ONLY hospital I would ever...even consider and I know my hospitals being a resident of Coachella Valley since 1954. Again my humblest thanks go out to everyone who made this a ............Karen Smith/Yucca Valley
in Surrey, British Columbia, Canada |
I'm from Canada and there I would have had to wait at least 1-1/2 years for a total hip replacement. From the time it took me to see Dr. DeSantis and have the surgery it was less than 3 weeks. I was also very happy with the outcome. I was out of the hospital the very next day and didn't experience any pain even without medication. Dr. DeSantis used the Anterior (from the front) approach for this surgery which isn't available back at home. I highly recommend Dr. DeSantis and all the staff at EMS.
in Palm Desert, CA |
I broke my hip and had a hip pinning. This painful injury exacerbated my pre-existing arthritis and Dr. DeSantis was recommended to me to perform a total hip replacement. Dr. DeSantis patiently answered my questions and quickly gained my confidence. He did an amazing job with the surgery itself and my recovery was uneventful. Dr. DeSantis will be my first choice should I ever need a joint replacement in the future and I would highly recommend him.
in Palm Springs, CA |
Dr. DeSantis is a 'no-nonsense, cut to the chase' type man that does excellent work
in La Quinta, CA |
Dr. De Santis has had the experience I was looking for ....over 5,000 knee replacements. He has a no nonsense approach to your situation, and gave me his honest assessment of my choices. My results have exceeded my expectations.
in Indio, Ca. |
I received a full hip replacement to my right hip 3 months ago. I'm 61 and put off this decision for 3 years. I had heard very positive reviews on Dr. De Santis's work. Dr. De Santis helped me to get back on the tennis court in 6 weeks. He was very optimistic with me from the very beginning that I would do well with this replacement. I just finished my first Palm Springs Tram Challenge. I'm excited to start my training for the next one a year from now.
in Palm Desert CA |
Dr DeSantis recently performed a Knee replacement for me. He was informative and made certain I knew the steps I needed to take for my recovery. Dr DeSantis and the entire team at Desert Orthopedic Center are highly professional and caring providers. I have the highest confidence in Dr DeSantis and his staff and will most definitely refer him. Thanks again Doctor
in Palm Springs, CA |
I developed severe osteoarthritis in both hips 6 years ago. I consulted a surgeon, but the surgery then was archaic (metal-on-metal/posterior entry). I qualified for the anterior approach/ bikini cut. Each hip was replaced in the same surgery 8 weeks ago. I highly recommend both at once, if possible. Dr. DeSantis and his superb assistant, David Delgadillo, performed a complicated surgery flawlessly. I can walk, swim and dance again! My life was given back to me. Words can't express my gratitude!
in Palm Desert, CA |
Dr. DeSantis is very professional & knowledgeable. He replaced my hip on 8-1-16. I was walking without a walker 10 days later. Now 3 weeks after & I am doing PT & swimming....should be back on the golf course soon. He is easy to talk to & has made me feel cared for whenever I see him.
in Palm Springs, CA |
Dr. De Santis did a total hip replacement on me on June 13, 2016. I've had wonderful results. Til today (August 23) I've traveled 3 times on planes, including once to France for a cruise on the Seine River. On August 9, less than 2 months post-op, in touring off the ship, I clocked 18,546 steps and 11 floors climbed (per my iPhone). In the last two days I did 2 hour long spin classes at the gym. Kudos to Dr. De Santis for a job well done.
in Palm Desert, CA |
I had a hip replaced by Dr. De Santis on Aug 15, 2016. It was an excellent experience. He is the best. I thank him from the bottom of my heart. I would also like to thank the professional attention and care I received from the Desert Orthopedic Center and The Eisenhower Medical Center in Rancho Mirage, California.
in Mountain Center |
On behalf of my husband, the recipient of hip replacement surgery, we would like to thank Dr De Santis for a successful surgery handled with the utmost professionalism and compassion. My husbands hip pain was the result of a motorcycle accident five years ago that was operated on by another surgeon, with the concept it could be screwed back together and would repair it's self. It never did. Dr De Santis literally gave my husband/us our lives back. We are thankful our paths crossed.
in Palm Springs, CA |
On the day Dr. John DeSantis took the Hippocratic Oath he did not just recite the words but made the oath an integral part of his life. He lives the Oath on a daily basis each time he sees a patient. Dr. DeSantis has earned my respect and trust and that is not easy from a former New Yorker. He is a man of great compassion and concern toward his patients. In January I saw him for bilateral knee replacement. He told me every detail & made sure I understood. Today I am able to walk thanks to him.
in Twentynine Palms, CA |
Dr. DeSantis is the best! I had severe degenerative in both my hips. I was turned away from another orthopedic due to my age and weight. Dr. DeSantis did not even hesitate on fixing my hips. Within 3 months I had a total hip replacement in both hips. I can't thank him enough for giving me my quality of life back. Thank you again Dr. DeSantis!!!
in palm desert, ca |
I recently had hip surgery performed by Dr. John De Santis. I considered myself very disabled before surgery as I was unable to walk without a cane and I was in constant pain. I was so pleased with my result! I had minimal pain immediately after surgery and my recovery time has been extremely brief. After just one month I was back doing activities with my family and friends again! Besides being a very skillful surgeon, Dr. De Santis is kind and compassionate. I highly recommend him!
in Palm Springs, CA |
He was professional and courteous
in Palm Desert, CA |
Dr. De Santis replaced my right hip and after thirty days the quality of my life is 100% better. The procedure went perfectly, I recovered steadily and can walk,swim and ride a bike. I thought Dr. De Santis was concerned and attentive, honest and straightforward and answered my questions well. The experience went very well and I would recommend Dr. De Santis to anyone needing a hip replacement in this area.
in Temecula, CA |
I knew a hip replacement was inevitable. After interviewing 3 highly recommended physicians in the IE, I was disappointed with them all. I found Dr. DeSantis on the DOC website and felt hopeful after watching his video. After meeting him in person, I knew I'd found my doctor. His technique and assurance that I'd enjoy a complete and successful recovery made it all less stressful. I was walking the same day and off the painkillers and walker after 2 weeks. Miracle worker! The very best in the IE!
in Palm Desert, CA |
Dr. DeSantis is a very competent surgeon who is very up-top-date on techniques for hip replacements. He answered all of my questions patiently. My surgery was very successful and I've resumed normal activities in 4 weeks.
in Rancho Mirage, CA |
Botched surgery--required revision by other doctor. No aftercare. Took no responsibility for pain caused by bad surgery. Told me to ignore severe pain--it was my fault! Had no interest in my problems. Don't ever go to this guy.
in Palm Springs, CA |
DON'T GO TO DESANTIS. He has a reputation with other doctors as being awful. He offers no aftercare. After he takes your money for surgery, he will tell you your pain is all in your head. He botched my hip surgery, Installed the piece incorrectly and permanently tore muscle while doing so. I now have a permanent injury due to him & may need a revision. He's known to be heavy handed which is just a polite way of saying he's clumsy. You don't need a bull in a china shop operating on you. AVOID!
in La Quinta, CA |
Have advised friends & family to avoid him. I found him to be as detached and disinterested as a doctor could be. After 3 months of unrelenting pain at the replaced hip, he took xrays and told me they looked great. So I was forced to get a 2nd opinion from another orthopedic surgeon, and a 3rd opinion from my neurolgist. Both delivered the same bad news. A complete, 2nd, hip replacement was necessary. So out of character/competence for a DOC physician.
in Palm Desert, CA |
I found Dr. DeSantis to be very compassionate and spent time with me. He answered all my questions.
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Dr. DeSantis accepts 1 insurance carrier
  • Accepts most major Health Plans. Please contact our office for details.

*Please verify this information when scheduling an appointment.

Hospitals where Dr. DeSantis has admitting privileges

Eisenhower Medical Center
39000 Bob Hope Drive
Rancho Mirage, CA 92270
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