Dr. Guarnaschelli's clinical focus has centered on breast and gynecologic cancers, especially IMRT, IGRT and brachytherapy techniques. Her clinical interest is in the field of women's health care. While at University of Cincinnati (2008-2013), Dr. Guarnaschelli participated in the education of UC medical students and residents interested in a career in Radiation Oncology. She has been a reviewer of oncologic papers for several journals. Dr. Guarnaschelli's research has been published in several journals including Practical Radiation Oncology, the Journal of Neuro-Oncology, and The Journal of Palliative Medicine. She has presented her research at a multitide of national conferences. In 2012, she was named to the Cincinnati Business Courier list of "40 under 40" award winners, recognizing the city's next generation of leaders and innovators.