Dr. Harris grew up in a small town in Iowa, where he also went to college and medical school. He met his wife, Dr. Holly Harris, while attending medical school. They got married while still in medical school. After graduation he completed his training in allergy while she finished hers in dermatology and dermatology surgery. They moved to South Bend in 1986, where they both joined the South Bend Clinic. They have three children and two grandchildren.
Dr. Jim Harris is an avid golfer, and an accomplished musician; he plays keyboards and sings regularly at local restaurants and other venues.