Dr. Brian Ladle, MD

Dr. Brian Ladle, MD

Pediatric Oncology  ·  
Male  ·  
Age 43
Dr. Brian Ladle, MD is a pediatric oncology specialist in Baltimore, MD. He graduated from Johns Hopkins University / School of Medicine and specializes in pediatric oncology and pediatrics.Read his story

1650 Orleans St

Baltimore, MD 21287

Contact Information

(410) 955-8817

Insurance Accepted

  • Blue Cross Blue Shield
  • CareFirst Blue Cross Blue Shield
  • Cigna
  • Coventry Health Care
  • Geisinger Health Plan
  • Humana
  • MultiPlan

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Dr. Ladle's bio

This content was provided by Dr. Ladle "Brian Ladle, M.D., Ph.D. began seriously considering a career in oncology back in high school, after seeing up close the toll that cancer treatments took on a close friend with Hodgkin's lymphoma. "I wanted to change that," he says. With Dr. Ladle's primary research focus on immunology, which involves using patients' own immune system to treat their cancer, he hopes to fulfill his teenage dream. "I'm striving to understand how cancer evades the immune system and to develop treatments that will overcome this inhibition," he explains. Currently, Dr. Ladle and his associates are applying this research focus in the laboratory, targeting sarcoma tumors. In their work to activate the immune system against sarcoma tumors, they are testing experimental vaccines in combination with different agents they believe will improve their effectiveness. In a related initiative, Dr. Ladle is exploring the possibility of using the body's existing immune cells found in bone marrow—through which many tumors spread—to improve immunity. By extracting immune cells, "enriching" them and then re-introducing them to a patient, they may help to enhance a patient's immune response. Dr. Ladle believes his research on experimental immunology management options is overdue. For the past 20 years, the standard of care treatment has remained relatively unchanged for the cancers in which he specializes, including osteosarcoma and other soft-tissue sarcomas like Ewing sarcoma. "Our progress has been so slow in treating these diseases. I hope immunotherapy can change that. Great advances are being seen in treating several adult cancers with immunotherapy. We are working to bring these same successes to pediatric sarcomas," he says. While the slow pace of developing new and improved treatment options can be frustrating, Dr. Ladle maintains a positive outlook. He finds reward in knowing that he is delivering the best care in the world, helping families through an extremely challenging time, and developing lasting relationships with both patients and family members. "Kids are so positive in general. They can be enduring awful things, but they do their best and enjoy the times they feel well. I love getting to know and work with the families. We work with incredible parents and siblings who will do anything for their child or brother or sister," he says. With his patients and their families in mind, Dr. Ladle is driven to do more. The toxicity of current treatments, and the fact that not all patients respond favorably motivates him. As he looks to the future, he sees immune therapy playing an increasingly larger role in pediatric cancers. "I hope to play a part in changing the paradigm of how pediatric cancers are treated, from mainly toxic chemotherapy to replacing them with immune-related agents that will provide potent treatment effects and long-term protection against their cancer returning," he says. "At the end of my career, I hope to sit down with families and lay out a treatment plan that will effectively treat their cancer without worry of infertility, growth problems, secondary cancers or life-threatening infections.""
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Care Philosophy

This content was provided by Dr. Ladle "A diagnosis of pediatric cancer is a very traumatic experience for the patient and their whole family. Our team works tirelessly to provide cutting-edge medical care but also emotional and social support through this difficult path."

2  Specialties

  • Pediatric Oncology
  • Pediatrics

1  Board Certifications

  • Pediatric Hematology-Oncology
    Accredited by: American Board of Pediatrics*

12  Conditions Treated

  • Adolescent Cancer
  • Blood Cancer
  • Bone Cancer
  • Cancer
  • Ewing's Sarcoma
  • Joint Cancer
  • Limb Cancer
  • Muscle Cancer
  • Neuroblastoma
  • Osteosarcoma
  • Pediatric Cancer
  • Rhabdomyosarcoma

3  Procedures

Background Check

Malpractice Claims not available

Healthgrades does not collect malpractice information for Maryland.

0 Sanctions

No sanctions history found for the years that Healthgrades collects data.

0 Board Actions

No board actions found for the years that Healthgrades collects data.


  • Johns Hopkins University / School of Medicine
    Medical School | Graduated
  • Cincinnati Children's Hospital Medical Center
    Residency Hospital | Completed
  • Johns Hopkins University / School of Medicine
    Fellowship Hospital | Completed
  • National Institutes of Health
    Fellowship Hospital | Completed

Awards & Recognition

Awards & Honors
  • Healthgrades Honor Roll
Media & Publications

Dr. Ladle has no media or publications listed.

Languages Spoken

  • English

Memberships & Professional Affiliations

Dr. Ladle does not have any memberships or affiliations listed. If you are Dr. Ladle and would like to add memberships or affiliations, please update your profile.

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