Dr. Alexander Khalessi, MD

Neurosurgery  |  
Insurances AcceptedSave
Dr. Alexander Khalessi, MD
Alexander A. Khalessi, MD, is a board-certified neurosurgeon who specializes in cranial and endovascular surgery. He is the vice chairman of clinical affairs in the Department of Neurosurgery, the director of endovascular neurosurgery and surgical director of neurocritical care. He provides both open surgical and catheter-based approaches to complex neurosurgical problems and offers alternative forms of treatment for cerebrovascular and cranial diseases. He is a fellow of the American Association of Neurological Surgeons (FAANS), American Heart Association Stroke Council (FAHA), and Senior Fellow of the Society of Neurointerventional Surgeons (SNIS). Dr. Khalessi is an active clinical leader in the field of neurosurgery and the treatment of cerebrovascular disease. He is the only neurosurgeon to serve on the Interventional Advisory Panel for the StrokeNet Steering Committee. Developed by National Institutes of Health (NIH), StrokeNet is a stroke trials network that conducts clinical trials and research studies to advance acute stroke treatment and prevention, and recovery and rehabilitation following a stroke. An expert in open cranial surgery, Dr. Khalessi also leads the National Football League's (NFL) Unaffiliated Neurotrauma Consultant Program in Southern California. His research interests include open surgical and endovascular therapies for intracranial aneurysms, extracranial carotid disease, large-vessel ischemic stroke, and intensive care management and prognosis in head injury. Dr. Khalessi has been a contributing author to the national guidelines efforts that define clinical practice standards, and was a writing group member the American Heart Association/American Stroke Association’s guidelines regarding both the extended use of IV-tPA and mechanical thrombectomy for ischemic stroke. Dr. Khalessi is a section editor for Cerebrovascular and Endovasular Neurosurgery for World Neurosurgery, the official journal of the World Federation of Neurological Societies (WFNS). He further chairs the Guidelines Committee for the CNS/AANS Joint Cerebrovascular Section and has authored Multi-Society Consensus Training Guidelines for Neurovascular Surgery. An associate professor for the Department of Surgery and Neurosciences, he directs national and international courses, including the intermediate resident course for the Society of Neurological Surgeons. Dr. Khalessi served on the Accreditation Council for Graduate Medical Education (ACGME) Residency Review Committee (RRC) for Neurological Surgery and the editorial board for the Journal of Graduate Medical Education. He was also named as an ACGME working group member for Neurosurgery and Endovascular Surgical Neuroradiology Milestone Projects. Prior to joining UC San Diego Health, Dr. Khalessi was a clinical instructor at the LAC + USC Medical Center. While there, he helped expand the hospital’s endovascular neurosurgery services. He completed his endovascular neurosurgery fellowship at SUNY Buffalo and neurosurgical residency at University of Southern California. Dr. Khalessi earned his medical degree at Johns Hopkins School of Medicine. He is board-certified in neurological surgery. Dr. Khalessi serves on the Executive Committee of the Congress of Neurological Surgeons (CNS) and represents the CNS and American Association of Neurological Surgeons to the American College of Radiology. Regionally, Dr. Khalessi served two terms as president of the San Diego Academy of Neurological Surgery.

200 W Arbor Dr

San Diego, CA 92103

Contact Information

(858) 657-7000

Dr. Alexander Khalessi, MD

Dr. Alexander Khalessi, MD

Accepted insurance

  • Aetna
  • Blue Cross Blue Shield
  • Blue Cross Blue Shield of California
  • Cigna
  • First Health (Coventry Health Care)
  • Molina Healthcare
  • MultiPlan

*Please verify this information when scheduling an appointment.

Learn about Dr. Khalessi

Dr. Khalessi's Experience

Dr. Khalessi's experience matches your search based on the following criteria:
  • Based on total number of patients treated over the last 12 months
  • Specializes in Neurosurgery
  • No malpractice claims found
  • No sanctions found
  • No board actions found


  • Neurosurgery

Board Certifications

Dr. Khalessi does not have any board certifications listed.


Conditions Treated

  • Acoustic Neuroma
  • Aneurysm
  • Bone Disorders
  • Brain Aneurysm
  • Brain Cancer
  • Brain Disorders
  • Brain and Nervous System Cancer (incl. Gliomas, Astrocytoma, Schwannoma, Medulloblastoma, Chordoma)
  • Cancer
  • Cerebral Artery Thrombosis
  • Cerebral Hemorrhage
  • Cerebrospinal Fluid Leak (CSF Leak)
  • Cerebrovascular Disease
  • Cervical Spine Myelopathy
  • Chiari's Deformity
  • Cranial Trauma
  • Degenerative Disc Disease
  • Ear Disorders
  • Epilepsy
  • Fracture
  • Hydrocephalus
  • Intervertebral Disc Disease
  • Low Back Pain
  • Meningiomas
  • Myelopathy
  • Normal Pressure Hydrocephalus
  • Osteoarthritis of Spine
  • Osteosarcoma
  • Pathological Spine Fracture
  • Pulmonary Arteriovenous Malformation
  • Radiculopathy (Not Due to Disc Displacement)
  • Rasmussen's Syndrome
  • Scoliosis
  • Secondary Malignancies
  • Spinal Cord Injury
  • Spinal Stenosis
  • Spine Deformities
  • Spine Disorders
  • Spine Fractures, Traumatic
  • Spondylolisthesis
  • Stroke
  • Subarachnoid Hemorrhage
  • Subdural Hemorrhage
  • Thoracic Spine Fracture
  • Thrombosis
  • Traumatic Brain Injury
  • Vascular Disease


Read More


  • Abscess or Fluid Incision and Drainage
  • Brain Surgery
  • Carotid Ultrasound
  • Cerebrospinal Fluid (CSF) Shunt - Insertion, Repair or Removal
  • Craniectomy, Craniotomy, Surgery of Skull Base, Neuroendoscopy
  • Herniated Disc Surgery
  • Intracranial Vessel Angioplasty and Stenting
  • Lamina Procedures (incl. Laminectomy, Laminoplasty, Laminotomy)
  • Spinal Fusion
  • Spinal Nerve Block
  • Spinal Reconstructive Surgery for Deformities
  • Stenting, Intracranial Vessels
  • Vascular Transcatheter Embolization

Background Check

0 Malpractice Claims

No malpractice history found for California.

0 Sanctions

No sanctions history found for the years that Healthgrades collects data.

0 Board Actions

No board actions found for the years that Healthgrades collects data.


  • Johns Hopkins Univ Sch Of Med
    Medical School | Graduated 2004

Awards & Recognition

Awards & Honors

Dr. Khalessi has no awards or honors listed.

Media & Publications

Dr. Khalessi has no media or publications listed.

Languages Spoken

  • English

Memberships & Professional Affiliations

Dr. Khalessi does not have any memberships or affiliations listed. If you are Dr. Khalessi and would like to add memberships or affiliations, please update your profile.

Dr. Khalessi's Reviews

Likelihood of recommending Dr. Khalessi to family and friends
based on 8 total reviews (3 with comments)
Dr. Khalessi's Performance
  • Trustworthiness
  • Explains condition(s) well
  • Answers Questions
  • Time well spent
Office & Staff Performance
  • Scheduling
  • Office environment
  • Staff friendliness
  • Average wait time
    31 to 45 minutes
Patient Comments (3)
in Menifee, CA |
Dr. Khalessi operated on me in November 2015. He inserted a brain stent for an aneurysm and saved my life. I thank God for him all the time! From the first meeting he put me at ease. He took time to answer questions and to explain what would happen. There are many skilled doctor's out there. But Dr. K is not only an expert at saving lives, his bedside manner is the best! I trust him and would recommend him to anyone in need of his specialized skills to save their lives! God Bless You Dr.K!!!!
in Imperial Beach, CA |
I highly recommend Dr. Khalessi. In 2014, he performed a craniotomy to clip an unruptured aneurysm. Since 2010, he's been my follow up neurologist for an aneurysm coil in 2009 by a Chicago doctor. Upon finding a second aneurysm on follow up, we first monitored it, then he clipped it. I had complete trust in him, his skills and his professionalism. The other doctors, nurses and staff around him are all great. I encourage anyone needing a neurosurgeon, to consider Dr. Khalessi. He changed my life.
Dr. Khalessi saved my life! He made my family and I feel comforted in a scary situation.
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Now Accepting New Patients
This provider offers the following appointment availability:
Same Day
Next Day
Dr. Khalessi accepts 7 insurance carriers
  • Aetna
    Aetna HMO
    Choice Plus POS II
  • Blue Cross Blue Shield
    Blue Card PPO
  • Blue Cross Blue Shield of California
    Advantage Preferred DirectAccess Plus PPO
    Blue Cross Blue Shield of California PPO
    Priority Select HMO
    Select Plus HMO
  • Cigna
    Cigna HMO
    Cigna PPO
    Open Access Plus
  • First Health (Coventry Health Care)
    First Health (Coventry Health Care) PPO
  • Molina Healthcare
  • MultiPlan
    MultiPlan PPO
    PHCS Network PPO

*Please verify this information when scheduling an appointment.

Hospitals where Dr. Khalessi has admitting privileges

UCSD Medical Center - Hillcrest
200 W Arbor Dr
San Diego, CA 92103
View Hospital Profile

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