Dr. Ali Khoynezhad, MD

Cardiovascular Surgery  ·  
Male  ·  
Age 48
Insurances Accepted  ·  Save
Dr. Ali Khoynezhad, MD
"Dr. Ali Khoynezhad is an internationally recognized leader in open, hybrid and endovascular aortic surgery and minimal-invasive atrial fibrillation procedures. He is Director of Aortic and Arrhythmia Surgery at MemorialCare Health System and Professor of Cardiovascular Surgery at the David Geffen School of Medicine at UCLA. As a board-certified cardiovascular surgeon, he performs all aspects of heart surgery including bypass operations and complex valve repair and replacements. He is an active industry consult and physician trainer, having trained over 550 surgeons and interventionalists in abdominal, thoracic endovascular aortic repair and atrial fibrillation procedures. Dr. Khoynezhad has been the principal investigator for 20 industry-sponsored clinical trials involving current and future generations of aortic stent grafts and cardiac devices, while taking the national and international principle investigator role in three clinical trials. Dr Khoynezhad's research findings have been published in 245 peer-reviewed medical journals, abstracts and book chapters, and his discoveries have resulted in many inventions and patents including percutaneous Endo-Bentall procedure and valve-in-valve TAVR for mechanical heart valves. Offering effective symptom relief and life-saving operations to his patients, gives Dr. Khoynezhad the greatest satisfaction in his professional life. "Seeing my patients and their families at follow-up visits is very rewarding…it literally charges my batteries. The stress of open-heart surgery can be overwhelming for my patients and their families. I provide patient-centered, high-quality care and spend a lot of time to explain procedures in detail. My patients can always count on me to be their advocate and supporter." After earning his bachelor's and medical degrees from the University of Cologne College of Medicine in Germany, Dr. Khoynezhad completed an internship in general surgery at Wake Forest University Baptist Medical Center in Winston-Salem, North Carolina. He completed his residency in general surgery at the North Shore University-Long Island Jewish Medical Center, Albert Einstein College of Medicine in New Hyde Park, New York. He also performed a cardiothoracic surgery residency at Montefiore Medical Center Affiliated Hospitals, Albert Einstein College of Medicine in the Bronx, a minimally-invasive cardiac surgery fellowship at Lenox Hill Hospital, and a vascular and endovascular surgery fellowship at Harbor-UCLA Medical Center, Torrance, California. "

Risks associated with the TAVR procedure include death, stroke and major bleeding

Important Risk Information for Patients


The Edwards SAPIEN 3 transcatheter heart valve, model 9600TFX, and accessories are indicated for relief of aortic stenosis in patients with symptomatic heart disease due to severe native calcific aortic stenosis who are judged by a Heart Team, including a cardiac surgeon, to be at intermediate or greater risk for open surgical therapy (i.e., predicted risk of surgical mortality ≥ 3% at 30 days, based on the Society of Thoracic Surgeons (STS) risk score and other clinical co-morbidities unmeasured by the STS risk calculator).

The Edwards SAPIEN 3 transcatheter heart valve, model 9600TFX, and accessories are indicated for patients with symptomatic heart disease due to failure (stenosed, insufficient, or combined) of a surgical bioprosthetic aortic or mitral valve who are judged by a heart team, including a cardiac surgeon, to be at high or greater risk for open surgical therapy (i.e., predicted risk of surgical mortality ≥ 8% at 30 days, based on the STS risk score and other clinical co-morbidities unmeasured by the STS risk calculator).

Contraindications (Who should not use):

The Edwards SAPIEN 3 transcatheter heart valve and delivery system should not be used in patients who:

  • Cannot tolerate medications that thin the blood or prevent blood clots from forming.
  • Have an active infection in the heart or elsewhere.


  • There may be an increased risk of stroke in transcatheter aortic valve replacement procedures, compared to other standard treatments for aortic stenosis in the high or greater risk population.
  • If an incorrect valve size for your anatomy is used, it may lead to heart injury, valve leakage, movement, or dislodgement.
  • Patients should talk to their doctor if they have significant heart disease, a mitral valve device or are allergic to chromium, nickel, molybdenum, manganese, copper, silicon, and/or polymeric materials.
  • The SAPIEN 3 valve may not last as long in patients whose bodies do not process calcium normally.
  • During the procedure, your doctors should monitor the dye used in the body; if used in excess it could lead to kidney damage. X-ray guidance used during the procedure may cause injury to the skin, which may be painful, damaging, and long-lasting.
  • Transcatheter aortic heart valve patients should take medications that thin the blood or prevent blood clots from forming, except when likely to have an adverse reaction, as determined by their physician. The Edwards SAPIEN 3 transcatheter heart valve has not been tested for use without medications that thin the blood or prevent blood clots from forming.


The long-term durability of the Edwards SAPIEN 3 transcatheter heart valve is not known at this time. Regular medical follow-up is recommended to evaluate how well a patient’s heart valve is performing. Safety, performance, and durability of the SAPIEN 3 valve has not been established for placement inside a previously implanted transcatheter valve.

The safety and effectiveness of the transcatheter heart valve is also not known for patients who have:

  • An aortic heart valve that is not calcified, contains only one or two leaflets, has leaflets with large pieces of calcium that may block the vessels that supply blood to the heart or in which the main problem is that the valve leaks.
  • Previous prosthetic ring in any position.
  • Previous atrial septal occlude.
  • A heart that does not pump well, has thickening of the heart muscle, with or without blockage, unusual ultrasound images of the heart that could represent irregularities such as a blood clot, a diseased mitral valve that is calcified or leaking, or Gorlin syndrome, a condition that affects many areas of the body and increases the risk of developing various cancers and tumors.
  • Low white, red or platelet blood cell counts, or history of bleeding because the blood does not clot properly.
  • Diseased, abnormal or irregularly shaped vessels leading to the heart. Vessels which are heavily diseased or too small for associated delivery devices, or a large amount of calcification at the point of entry.
  • Allergies to blood-thinning medications or dye injected during the procedure.
  • For a valve in valve procedure, there is a risk of leakage if the previously implanted tissue valve is not securely in place or if it is damaged. There is also the possibility that a partially detached valve leaflet from the previously implanted valve could block a blood vessel.
  • Additional pre-procedure imaging will be completed to evaluate proper sizing.

Potential risks associated with the procedure include:

  • Death, stroke, paralysis (loss of muscle function), permanent disability, or severe bleeding.
  • Risks to the heart, including heart attack or heart failure, a heart that does not pump well, irregular heartbeat that may result in a need for a permanent pacemaker, chest pain, heart murmur, false aneurysm, recurring aortic stenosis(narrowing), too much fluid around the heart, injury to the structure of the heart.
  • Risks to your lungs or breathing, including difficulty breathing, fainting, buildup of fluid in or around the lungs, weakness or inability to exercise.
  • Risks involving bleeding or your blood supply, including formation of a blood clot, high or low blood pressure, limited blood supply, a decrease in red blood cells, or abnormal lab values, bleeding in the abdominal cavity, collection of blood under the skin.
  • Additional risks, including life-threatening infection, dislodgement of calcified material, air embolism (air bubbles in the blood vessels), poor kidney function or failure, nerve injury, fever, allergic reaction to anesthesia or dye, reoperation, pain, infection or bleeding at incision sites, or swelling.

Additional potential risks specifically associated with the use of the heart valve include:

  • Valve movement after deployment, blockage or disruption of blood flow through the heart, need for additional heart surgery and possible removal of the SAPIEN 3 valve, a blood clot that requires treatment, damage to the valve (e.g., wear, breakage, recurring aortic stenosis), nonstructural valve dysfunction (e.g., leakage, inappropriate sizing or positioning, blockage, excess tissue in growth, blood cell damage, etc.) or mechanical failure of the delivery system and/or accessories.

CAUTION: Federal (United States) law restricts these devices to sale by or on the order of a physician.

Edwards, Edwards Lifesciences, the stylized E logo, Edwards SAPIEN, Edwards SAPIEN 3, SAPIEN, and SAPIEN 3 are trademarks of Edwards Lifesciences Corporation. All other trademarks are the property of their respective owners.

© 2017 Edwards Lifesciences Corporation. All rights reserved. PP--US-2507 v1.0

Edwards Lifesciences One Edwards Way, Irvine CA 92614 USA edwards.com

3828 Schaufele Ave Ste 340

Long Beach, CA 90808

Contact Information

(657) 241-9052

Dr. Ali Khoynezhad, MD

Dr. Ali Khoynezhad, MD

Accepted insurance

  • Accepts most major Health Plans. Please contact our office for details.

*Please verify this information when scheduling an appointment.

Background Check

No malpractice claims found for California
No disciplinary actions found for the years we collect data
No board actions found for the years we collect data
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Experience Check

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Dr. Khoynezhad's Top Procedures and Conditions

Treatment Frequency

Treatment Frequency

Dr. Khoynezhad treats Aneurysm more than 86% of his peers

Dr. Khoynezhad treats this condition more than 86% of his peers

Rating Includes other areas of care:

  • Abdominal Aortic Aneurysm
  • Aneurysm and Dissection of Heart
  • Aneurysm of Sinus of Valsalva
  • Aneurysm, Intracranial Berry
  • Aneurysm, Intracranial Berry, 1
  • Aneurysm, Intracranial Berry, 2
  • Aneurysm, Intracranial Berry, 3
  • Aneurysm, Intracranial Berry, 4
  • Aneurysm, Intracranial Berry, 5
  • Aneurysm, Intracranial Berry, 6
  • Aneurysm, Intracranial Berry, 7
  • Aneurysm, Intracranial Berry, 8
  • Aortic Aneurysm
  • Aortic Aneurysm, Familial Abdominal 1
  • Aortic Aneurysm, Familial Thoracic 1
  • Cerebral Aneurysm
  • Congenital Aneurysms of the Great Vessels
  • Coronary Artery Aneurysm
  • Dissecting Aneurysm
  • Endovascular Aortic Aneurysm
  • False Aneurysm
  • Femoral Aneurysm
  • Fetal Left Ventricular Aneurysm
  • Iliac Aneurysm
  • Leber Miliary Aneurysm
  • Popliteal Aneurysm
  • Pulmonary Arteriovenous Aneurysm
  • Retinal Macoaneurysm
  • Ruptured Aneurysm
  • Saccular Aneurysm
  • Suprarenal Aneurysm
  • Vein of Galen Aneurysm
  • Visceral Aneurysm
Aortic Aneurysm

Treatment Frequency

Dr. Khoynezhad treats Aortic Aneurysm more than 85% of his peers

Dr. Khoynezhad treats this condition more than 85% of his peers

Rating Includes other areas of care:

  • Abdominal Aortic Aneurysm
  • Aortic Aneurysm, Familial Abdominal 1
  • Aortic Aneurysm, Familial Thoracic 1
  • Endovascular Aortic Aneurysm
Aortic Dissection

Treatment Frequency

Dr. Khoynezhad treats Aortic Dissection more than 73% of his peers

Dr. Khoynezhad treats this condition more than 73% of his peers

Dr. Khoynezhad's conditions and procedures:

Abdominal Aortic Aneurysm (AAA)
Abdominal Aortic Aneurysm Repair
Ablation for Treatment of Atrial Fibrillation
Ablation for Treatment of Cardiac Arrhythmias
Abnormal Heart Beat
Abscess or Cyst Drainage or Aspiration
Abscess or Fluid Incision and Drainage
Aneurysm of Sinus of Valsalva
Aneurysm Stenting
Aneurysm Surgery
Angina and Acute Coronary Syndrome
Aorta-Pulmonary Artery Fistula
Aortic Aneurysm
Aortic Aneurysm Repair
Aortic Aneurysm Stent Grafting
Aortic Aneurysm, Familial Abdominal
Aortic Aneurysm, Familial Thoracic
Aortic Arch Anomaly
Aortic Arch Anomaly - Peculiar Facies - Mental Retardation
Aortic Arch Interruption
Aortic Dilatation - Joint Hypermobility - Arterial Tortuosity
Aortic Dilation
Aortic Diseases
Aortic Dissection
Aortic Ectasia
Aortic Embolism and Thrombosis
Aortic Repair, Open or Repair of Arterial Aneurysm, Open
Aortic Stenosis
Aortic Supravalvular Stenosis
Aortic Valve Disease
Aortic Valve Regurgitation
Aortic Valve Replacement
Aortic Valve Surgery
Aortoenteric Fistula
Arterial Insufficiency
Arterial Occlusive Disease
Arterial Occlusive Disease, Progressive - Hypertension - Heart Defects - Bone Fragility - Brachysyndactyly
Arterial Tortuosity Syndrome
Arteriosclerosis Obliterans
Arteriovenous Fistula
Arteriovenous Malformation
Artery Disorders
Atrial Fibrillation
Atrial Flutter
Automatic Implantable Cardioverter Defibrillator (ICD) Implantation
Bacterial Endocarditis
Balloon Angioplasty
Behçet's Disease
Benign Tumor
Bicuspid Aortic Valve
Cardiac Catheterization (incl. Coronary Angiography)
Cardiac Electrophysiology
Cardiac Imaging
Cardiac MRI (Magnetic Resonance Imaging) of Heart or Chest
Cardiac Sources of Embolism
Cardiac Surgery in the Elderly
Cardiac Tamponade
Cardiomyopathy, Takotsubo
Cardiopulmonary Conditions
Cardiovascular Disease
Cardiovascular Intervention
Cardioverter-Defibrillator or Pacemaker Insertion, Removal or Repair
Carotid Artery Disease
Chest CT (incl. Heart and Lungs)
Coarctation of Aorta, Dominant
Coarctation of the Aorta
Congenital Aortic Valve Disorders
Congenital Cardiovascular Malformations
Congenital Heart Defects
Congenital Heart Disease
Congenital Malformation
Congestive Heart Failure
Coronary Angioplasty, Atherectomy and Stent
Coronary Artery Aneurysm
Coronary Artery Bypass Graft (CABG) Surgery
Coronary Artery Calcification
Coronary Artery Disease (CAD)
Coronary Artery Disease, Autosomal Dominant 1
Coronary Artery Disease, Autosomal Dominant 2
Coronary Artery Dissection
Coronary Artery Fistula
Coronary Heart Disease, Susceptibility to, 1
Decortication and Pleurectomy
Defibrillator Implantation
Dissecting Aneurysm
Ehlers-Danlos Syndrome
Ehlers-Danlos Syndrome, Cardiac Valvular Form
Ehlers-Danlos Syndrome, Type 4
Endovascular Aneurysm Repair
Endovascular Disorders
Endovascular Procedure
Endovascular Repair of Abdominal Aortic Aneurysm
Endovascular Repair of Aorta
Endovascular Repair of Thoracic Aorta
Endovascular Stent Grafting
Esophageal Cancer
Esophageal Diseases
Esophageal Surgery
Head and Neck Cancer
Head and Neck Surgery
Heart Attack (Acute Myocardial Infarction)
Heart Block
Heart Block Progressive, Familial
Heart Blood Vessel Blockage
Heart Cancer
Heart Defect Repair
Heart Disease
Heart Disease in Women
Heart Injuries
Heart Murmur
Heart Palpitations
Heart Surgery
Heart Transplant
Heart Transplant Rejection
Heart Tumors, Benign
Heart Valve Diseases
Heart Valve Replacement
Heart Valve Surgery
Hernia Repair
Hypertension, Coarctation of the Aorta-Induced
Hypertensive Heart Disease
Impella Device
Insertion of Epicardial Lead for Pacemaker or Cardioverter and-or Defibrillator
Lobectomy, Open
Loeys-Dietz Syndrome
Lung Cancer
Lung Removal (Partial or Complete): Open, or Resection of Lung Tumor: Open
Lung Surgery
Lung Transplant
Marfan Syndrome
Marfan Syndrome, Type 2
Marfan-Like Syndrome
Marfan-Like Syndrome, Boileau Type
Maze Procedure
Minimally Invasive Aneurysm Repair
Minimally Invasive Heart Surgery
Minimally Invasive Valve Surgery
Mitral Valve Disease
Mitral Valve Prolapse
Mitral Valve Prolapse, Familial, Autosomal Dominant
Mitral Valve Prolapse, Familial, X-Linked
Mitral Valve Prolapse, Myxomatous 1
Mitral Valve Prolapse, Myxomatous 2
Mitral Valve Prolapse, Myxomatous 3
Mitral Valve Regurgitation
Mitral Valve Stenosis
Mitral Valve Surgery
Non-Coronary Angioplasty, Atherectomy, and Stenting
Off-Pump Coronary Artery Bypass Graft (CABG) Surgery
Off-Pump Coronary Artery Revascularization Surgery
Off-Pump Coronary Surgery
Open Diaphragmatic and-or Paraesophageal Hiatal Hernia Repair
Pacemaker Insertion or Replacement
Pacemaker Monitoring
Pacemaker Therapy for Heart Failure
Paroxysmal Atrial Tachycardia
Paroxysmal Supraventricular Tachycardia
Patent Ductus Arteriosus
Percutaneous Balloon Valvuloplasty
Percutaneous Management of Valvular Heart Disease
Percutaneous Procedures
Pericardial Disease
Pericardial Effusion
Pericardial Mesothelioma
Peripheral Angioplasty
Peripheral Arterial Aneurysm
Peripheral Arterial Aneurysm and Dissection
Peripheral Arterial Dissection
Peripheral Artery Catheterization
Peripheral Vascular Intervention
Port Placements or Replacements
Pulmonary Arteriovenous Malformation
Pulmonary Disease
Pulmonary Embolism
Pulmonary Valve Disease
Removal or Revision of Pacemaker or Cardioverter and-or Defibrillator
Ruptured Aneurysm
Ruptured Aortic Aneurysm
Secondary Hypertension
Segmentectomy, Open
Septal Defect
Stent Grafting
Symptoms, Heart
Takayasu's Arteritis
Thoracic Aortic Aneurysm
Thoracoabdominal Aortic Aneurysm
Thoracoscopic Procedure
Thoracoscopic Wedge Resection
Thromboendarterectomy or Excision of Infected Graft
Tracheal Surgery
Transcatheter Aortic Valve Replacement (TAVR)
Tricuspid Valve Surgery
Valve Repair or Replacement (Aortic, Mitral, Tricuspid, and Pulmonary)
Valvular Regurgitation
Valvular Stenosis
Vascular Disease
Vascular Procedure
Vascular Stenting
Vascular Surgical Procedure
Video-Assisted Thoracoscopic Surgery (VATS) or Thoracotomy

About Me

Care Philosophy

I truly care about my patients and their families, and spend much time before the operation to explain the nature of the disease and the surgical/procedural options. After the operation, I spend time as coach and cheerleader to advance you through...


  • Cardiovascular Surgery

Board Certifications

  • Cardiovascular Surgery
  • Thoracic Cardiovascular Surgery


  • 2005
    Montefiore Medical Center
    Residency Hospital
  • 2003
    North Shore University Hospital
    Residency Hospital
  • 1999
    Wake Forest University
    Internship Hospital
  • 1998
    Charite University Medical Center
    Residency Hospital
  • 1996
    University Of Cologne
    Medical School


  • Farsi
  • German
  • Spanish
  • English


Dr. Khoynezhad's Reviews

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Dr. Khoynezhad's Performance
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Office & Staff Performance
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What People Say About Dr. Ali Khoynezhad, MD
RecentMost Helpful
Dr. Khoynezhad was very professional in my dealings with him. He explained everything and then asked if there was anything else he could answer. He shows genuine concern for his patients and wants to help where he can. Very refreshing.
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Dr. Khoynezhad performed my surgery at Cedars Sinai, January, 2010. I had an Ascending Aortic Aneurysm and bicuspid aortic valve. He replaced the aorta and arch and repaired the valve. I was living in Colorado then, but he was recommended to me by my Interventional Cardiologist at Scripps, La...Read More
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I feel very fortunate to have found Dr. Ali Khoynezhad and the very skilled staff at Cedars-Sinai Hospital. Although there is nothing overly pleasant about having open heart surgery, I can say that Dr. Khoynezhad and the Hospital Staff involved did everything in their power (from start to finish)...Read More
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Dr Khoynezhad operated on my son in September 2015. What a wonderful and caring man. I travelled from Australia to LA to help my son recover and was just amazed at the care that was given by himself and the hospital.
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Insurance accepted

Accepted insurance can change. Please double-check when making an appointment.

Accepts most major Health Plans. Please contact our office for details.

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