Prednisone TABLET

Get an overview of PREDNISONE (tablet), including its generic name, formulation (i.e. pill, oral solution, injection, inhaled medicine) and why it’s used. The medication in Prednisone can be sold under different names.

Refer to the “Also Known As” section to reference different products that include the same medication as Prednisone.

Drug Basics

Brand Name: Prednisone

Generic Name: PREDNISONE

Drug Type: HUMAN PRESCRIPTION DRUG

Route: ORAL

Dosage Form: TABLET

Data Current As Of: 2018-10-11

indications & usage

Prednisone tablets are indicated in the following conditions:

1. Endocrine Disorders:

Primary or secondary adrenocortical insufficiency (hydrocortisone or cortisone is the first choice; synthetic analogs may be used in conjunction with mineralocorticoids where applicable; in infancy mineralocorticoid supplementation is of particular importance).

Congenital adrenal hyperplasia

Nonsuppurative thyroiditis

Hypercalcemia associated with cancer

2. Rheumatic Disorders

As adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in:

Psoriatic arthritis

Rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy)

Ankylosing spondylitis

Acute and subacute bursitis

Acute nonspecific tenosynovitis

Acute gouty arthritis

Post-traumatic osteoarthritis

Synovitis of osteoarthritis

Epicondylitis.

3. Collagen Diseases

During an exacerbation or as maintenance therapy in selected cases of:

Systemic lupus erythematosus

Systemic dermatomyositis (polymyositis)

Acute rheumatic carditis

4. Dermatologic Diseases

Pemphigus

Bullous dermatitis herpetiformis

Severe erythema multiforme (Stevens-Johnson syndrome)

Exfoliative dermatitis

Mycosis fungoides

Severe psoriasis

Severe seborrheic dermatitis

5. Allergic States

Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment:

Seasonal or perennial allergic rhinitis

Bronchial asthma

Contact dermatitis

Atopic dermatitis

Serum sickness

Drug hypersensitivity reactions

6. Ophthalmic Diseases

Severe acute and chronic allergic and inflammatory processes involving the eye and its adnexa such as:

Allergic corneal marginal ulcers

Herpes zoster ophthalmicus

Anterior segment inflammation

Diffuse posterior uveitis and choroiditis

Sympathetic ophthalmia

Allergic conjunctivitis

Keratitis

Chorioretinitis

Optic neuritis

Iritis and iridocyclitis

7. Respiratory Diseases

Symptomatic sarcoidosis

Loeffler's syndrome not manageable by other means

Berylliosis

Fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy

Aspiration pneumonitis

8. Hematologic Disorders

Idiopathic thrombocytopenic purpura in adults

Secondary thrombocytopenia in adults

Acquired (autoimmune) hemolytic anemia

Erythroblastopenia (RBC anemia)

Congenital (erythroid) hypoplastic anemia

9. Neoplastic Diseases

For palliative management of:

Leukemias and lymphomas in adults

Acute leukemia of childhood

10. Edematous States

To induce a diuresis or remission of proteinuria in the nephrotic syndrome, without uremia, of the idiopathic type or that due to lupus erythematosus

11. Gastrointestinal Diseases

To tide the patient over a critical period of the disease in:

Ulcerative colitis

Regional enteritis

12. Nervous System

Acute exacerbations of multiple sclerosis

13. Miscellaneous

Tuberculous meningitis with subarachnoid block or, impending block when used concurrently with appropriate antituberculous chemotherapy.

Trichinosis with neurologic or myocardial involvement.

contraindications

Prednisone tablets are contraindicated in systemic fungal infections and known hypersensitivity to components.

adverse reactions

Fluid and Electrolyte Disturbances:

Sodium retention.

Fluid retention.

Congestive heart failure in susceptible patients.

Potassium loss.

Hypokalemic alkalosis.

Hypertension.

Musculoskeletal:

Muscle weakness.

Steroid myopathy.

Loss of muscle mass.

Osteoporosis.

Vertebral compression fractures.

Aseptic necrosis of femoral and humeral heads.

Pathologic fracture of long bones.

Gastrointestinal:

Peptic ulcer with possible perforation and hemorrhage.

Pancreatitis.

Abdominal distention.

Ulcerative esophagitis.

Dermatologic:

Impaired wound healing.

Thin fragile skin.

Petechiae and ecchymoses.

Facial erythema.

Increased sweating.

May suppress reactions to skin tests.

Metabolic:

Negative nitrogen balance due to protein catabolism.

Neurological:

Convulsions

Increased intracranial pressure with papilledema (pseudo-tumor cerebri) usually after treatment.

Vertigo.

Headache.

Endocrine:

Menstrual irregularities.

Development of Cushingoid state.

Suppression of growth in children.

Secondary adrenocortical and pituitary unresponsiveness, particularly in times of stress, as in trauma, surgery or illness.

Decreased carbohydrate tolerance.

Manifestations of latent diabetes mellitus.

Increased requirements for insulin or oral hypoglycemic agents in diabetics.

 Ophthalmic:

Posterior subcapsular cataracts.

Increased intraocular pressure.

Glaucoma.

Exophthalmos.

Additional Reactions:

Urticaria and other allergic, anaphylactic or hypersensitivity reactions.


also known as

This drug label information is as submitted to the Food and Drug Administration (FDA) and is intended for informational purposes only. If you think you may have a medical emergency, immediately call your doctor or dial 911. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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