Cabometyx (cabozantinib)

Cabometyx is a brand-name prescription medication. It’s approved by the Food and Drug Administration (FDA) to treat the following conditions.

• Advanced renal cell carcinoma (RCC). Doctors can prescribe Cabometyx to treat advanced RCC in adults. RCC is the most common type of kidney cancer.
• Advanced RCC in combination with another drug. Doctors can prescribe Cabometyx to treat advanced RCC in adults in combination with the drug nivolumab (Opdivo). Nivolumab also treats kidney cancer. Doctors may prescribe these medications together as a first treatment option for RCC.
• Hepatocellular carcinoma (HCC). Doctors can prescribe Cabometyx to treat HCC in adults. HCC is a type of liver cancer. The drug is used in people who have taken sorafenib (Nexavar) in the past for treating HCC.
• Advanced or metastatic differentiated thyroid cancer (DTC). Doctors can prescribe Cabometyx to treat DTC that is advanced or metastatic. (Metastatic means the cancer has spread to other parts of the body.) Cabometyx can be prescribed for DTC in certain adults and children ages 12 years and older if certain other treatments weren’t effective in treating their DTC or cannot be used.

Cabometyx is approved to treat these conditions in certain situations. For details about these conditions and how the drug treats them, see the “Cabometyx: Uses” section below.

The following table provides key facts about Cabometyx.

If you’re interested in taking this drug, search here to find a doctor who might prescribe it.

Cabometyx contains the active drug cabozantinib. It only comes as a brand-name medication. And it isn’t currently available as a generic drug.

A generic is an identical copy of the active drug found in a brand-name medication. Generics typically cost less than brand-name drugs.

As with most drugs, it’s possible to have side effects with Cabometyx. These can include some mild side effects, but also some serious ones.

To learn more about Cabometyx’s side effects, talk with your doctor or pharmacist. They may also provide information about managing certain side effects of this drug.

Note: The Food and Drug Administration (FDA) tracks side effects of drugs it has approved. If you would like to notify the FDA about a side effect you’ve had with Cabometyx, you can do so through MedWatch.

Mild and serious side effects of Cabometyx are listed in the table below. This table does not include all of Cabometyx’s possible side effects.

* This is not a complete list of Cabometyx’s mild side effects. To learn about other mild side effects of this drug, ask your doctor or pharmacist. Or you can view the drug’s prescribing information.
† For more information on allergic reactions with Cabometyx, see below.

Most times, mild side effects of a drug go away within a few days or a couple of weeks. Talk with your doctor or pharmacist if any side effects become severe or don’t go away.

Serious side effects from Cabometyx aren’t common, but they are possible. If you have serious side effects, call your doctor right away. However, if you’re having a medical emergency or your symptoms feel life threatening, call 911 or a local emergency number.

Below, you’ll find dosages that are commonly recommended for Cabometyx. However, you should take the dosage your doctor prescribes for you. They’ll recommend the dosage that’s best for your needs.

Most often, doctors start by prescribing the recommended dosage of Cabometyx. Then, they may change the dosage over time to an amount that’s right for you. Doctors typically prescribe the smallest dosage that gives the desired outcome.

The dosage of Cabometyx that your doctor prescribes will depend on factors such as:

• any health conditions you have
• other medications that you’re taking
• the condition you’re taking Cabometyx to treat
• side effects that you experience from Cabometyx
• your body surface area (a calculation based on your weight and height) in children taking the drug

Cabometyx is available as follows.

• Form: oral tablet
• Strengths:
  • 20 milligrams (mg)
  • 40 mg
  • 60 mg

Recommended dosages for Cabometyx in adults and children are described below.

The recommended dosage for Cabometyx in adults with renal cell carcinoma (RCC) is as follows.

• Dose: 60 mg
• Frequency: once daily

The recommended dosage for Cabometyx in adults with RCC who are also taking nivolumab (Opdivo) is as follows.

• Dose: 40 mg
• Frequency: once daily

The recommended dosage for Cabometyx in adults with hepatocellular carcinoma (HCC) is as follows.

• Dose: 60 mg
• Frequency: once daily

The recommended dosage for Cabometyx to treat differentiated thyroid cancer (DTC) in adults is as follows.

• Dose: 60 mg
• Frequency: once daily

Your doctor may prescribe a different dosage of Cabometyx depending on several factors, including whether you have other medical conditions, other medications that you take, and side effects that you have. If you have questions about the dosage that’s right for you, talk with your doctor.

The recommended dosage for Cabometyx in children with DTC is based on their body surface area (BSA). Your child’s doctor or pharmacist will calculate their BSA using a formula that includes the child’s height in centimeters (cm) and weight in kilograms (kg). BSA is measured in meters squared (m²). This number will help them determine the best Cabometyx dose for your child.

If a child with DTC has a BSA of 1.2 m² or more, they will take the following dosage.

• Dose: 60 mg
• Frequency: once daily

If a child with DTC has a BSA of less than 1.2 m², they will take the following dosage.

• Dose: 40 mg
• Frequency: once daily

Your doctor may prescribe a different dosage of Cabometyx depending on several factors, including whether you have other medical conditions, other medications that you take, and side effects that you have. If you have questions about the dosage that’s right for you, talk with your doctor.

Below are some things to consider about Cabometyx’s dosage.

• Missing a dose. If you miss a dose of Cabometyx and your next dose of medication is less than 12 hours away, skip your missed dose. If your dose is more than 12 hours away, take your missed dose of medication as soon as you remember. If you miss your dose of Cabometyx and you’re unsure when to take your next dose, call your doctor or pharmacist. They can help you determine when you should take your next dose of Cabometyx. Try these tips to help avoid missing doses. You could also set an alarm, use a timer, or download a reminder app on your phone.
• Length of treatment. Doctors typically prescribe Cabometyx as a long-term treatment. You’ll likely take it long term if you and your doctor feel it’s safe and effective for your condition. In most cases, people will continue taking Cabometyx until their condition worsens. Or, they may stop taking Cabometyx due to side effects from the medication.

Here are some common questions about Cabometyx and brief answers to them. If you’d like to know more about these topics, ask your doctor.

The life expectancy with Cabometyx treatment depends on a variety of factors. (Life expectancy describes how long a person may expect to live.) These factors include:

• the type of cancer you have
• how severe the cancer is
• other medications you’re taking

In clinical studies, Cabometyx increased the average life expectancy of people who took the drug compared with people who took another medication or a placebo. (A placebo is a treatment with no active drug.)

Each person taking Cabometyx may have a different experience. So this medication may impact your life expectancy differently than how it affected people in clinical studies. To find out more information about your condition and life expectancy, talk with your doctor.

To learn more about how Cabometyx may work for you, see the manufacturer’s webpage.

No, Cabometyx should not cause any eye-related side effects. In clinical studies, eye-related side effects were not reported by people taking the drug.

That said, if you have eye-related symptoms while taking Cabometyx, they may be due to other possible side effects of the drug. For example, the medication may cause the following:

• High blood pressure, including hypertensive crisis. And hypertensive crisis can cause vision changes, such as blurry vision.
• Reversible posterior leukoencephalopathy syndrome (PRES). This condition may cause vision changes, such as blurry vision or even vision loss.
• Stroke, which is a rare but serious side effect of Cabometyx. And difficulty seeing out of one or both eyes can be a sign of a stroke.

Additionally, Cabometyx may cause liver problems. One symptom of liver problems is yellowing of the eyes or skin.

If you are experiencing mild eye-related side effects during treatment with Cabometyx, talk with your doctor. They can help you determine the cause of the symptoms and the best way to treat them.

However, hypertensive crisis, PRES, and stroke are life threatening medical emergencies that require immediate medical treatment. Call 911 or go to your local emergency room right away if you notice symptoms of these side effects.

No, Cabometyx is not a chemotherapy drug. Instead, Cabometyx belongs to a drug class called tyrosine kinase inhibitors (TKIs).

TKIs are considered targeted therapies. They target (work on) specific traits of cancer cells. To learn more about how Cabometyx works, see the “Cabometyx: How it works” section below.

In comparison, chemotherapy drugs work by killing fast-growing cells. Because cancer cells are fast growing, this helps stop their growth. However, in addition to killing cancer cells, chemotherapy also kills fast-growing healthy cells. This is what causes many of the side effects of chemotherapy drugs.

Doctors may prescribe drugs other than Cabometyx for your condition. Certain drugs may work better for you than others.

Cabometyx is used to treat specific types of kidney cancer, liver cancer, and thyroid cancer in certain situations. To learn more about what types of cancer Cabometyx treats, view “Cabometyx: Uses” below for more information.

Here are summaries of other treatments doctors sometimes prescribe for kidney cancer and liver cancer.

To learn more about one alternative to Cabometyx, view the following article:

• Cabometyx vs. Cometriq

For more information about alternatives to Cabometyx, ask your doctor. They can tell you about other medications that could be prescribed for your condition.

Prescription drugs, such as Cabometyx, are approved by the Food and Drug Administration (FDA) to treat certain conditions.

Cabometyx is approved for use in adults to treat a type of kidney cancer called renal cell carcinoma (RCC).

RCC is the most common type of kidney cancer. It can occur when cells in the tubules of your kidneys grow abnormally or very quickly. This cell growth can cause a tumor.

Symptoms of RCC may include:

• bloody urine
• pain in the side of the abdomen
• weight loss
• decreased appetite

Cabometyx can be used alone for advanced RCC. It can also be used in combination with nivolumab (Opdivo) as a first treatment option for advanced RCC.

Cabometyx is approved for use in adults to treat a type of liver cancer called hepatocellular carcinoma (HCC).

HCC can occur if hepatocytes (certain cells in the liver) grow abnormally or very quickly.

Symptoms of HCC may include:

• nausea
• weight loss
• fatigue
• yellowing of the eyes or skin

For HCC, Cabometyx should be used if you have already tried another medication called sorafenib (Nexavar).

Cabometyx can be used to treat a type of thyroid cancer called differentiated thyroid cancer (DTC).

DTC may occur when cells in your thyroid gland grow abnormally or very quickly. The thyroid gland is located in the neck. It’s responsible for managing your metabolism, heart rate, and digestion.

Symptoms of DTC may include:

• a lump or swelling in the neck
• difficulty swallowing
• cough
• trouble breathing

Cabometyx can be used to treat DTC that’s advanced or metastatic (has spread to other areas of the body). Doctors can prescribe the drug for adults and children ages 12 years and older.

For this purpose, Cabometyx should only be used if:

• you have already tried another type of medication called a VEGFR-targeted medication and your thyroid cancer progressed despite treatment
• you cannot use radioactive iodine treatment

In some cases, your doctor may recommend Cabometyx in combination with other medications to treat your condition. Specifically, Cabometyx can be taken with nivolumab (Opdivo) to treat renal cell carcinoma (RCC).

When you start treatment with Cabometyx, your doctor will discuss your treatment plan with you. They can determine whether you’ll be taking Cabometyx alone or with other medications.

Cabometyx is approved to treat a type of thyroid cancer called differentiated thyroid cancer (DTC) in children ages 12 years and older. To learn about this condition, see “Using Cabometyx for thyroid cancer” above.

If you have one of the conditions described above and you’re interested in taking Cabometyx, talk with your doctor. Use this link if you need help finding a doctor or healthcare professional. Before your appointment, you can also see the appointment guide for cancer to help prepare for your visit.

There are no known interactions between alcohol and Cabometyx.

However, it’s possible that alcohol may worsen any side effects you may have from Cabometyx. For example, Cabometyx can cause nausea and vomiting. Drinking alcohol may also cause nausea and vomiting. So drinking alcohol while you’re taking Cabometyx may increase your risk of these side effects.

It’s also possible that alcohol may increase your risk of more serious side effects due to Cabometyx. For instance, this medication can cause liver problems. Drinking alcohol may also cause liver problems. So drinking alcohol while taking Cabometyx can increase your risk of this side effect.

If you drink alcohol, talk with your doctor about whether it’s safe for you to drink while taking Cabometyx.

Cabometyx may interact with other medications, certain supplements, and certain foods.

Different interactions can cause different effects. Some interactions can interfere with a drug’s effectiveness. Others can increase a drug’s side effects or cause them to be severe.

If any of the interactions listed below might pertain to you, talk with your doctor. They can tell you what you need to do to avoid the interaction.

• Cabometyx and certain drugs that affect CYP3A4. CYP3A4 is an enzyme (type of protein) that breaks down Cabometyx. Taking Cabometyx with certain drugs that affect this enzyme may not be recommended. If your doctor has you take Cabometyx with any of these drugs, your doctor may adjust your dose of Cabometyx. Examples include:
  • cobicistat (Tybost)
  • ritonavir (Norvir)
  • clarithromycin
  • nefazodone
  • phenytoin (Dilantin)
  • rifampin (Rimactane)
  • carbamazepine (Tegretol, others)
  • apalutamide (Erleada)
• Cabometyx and herbs and supplements. Certain herbs and supplements may interact with Cabometyx. Examples include:
  • St. John’s wort
• Cabometyx and foods. Certain medications interact with foods. Examples of foods that may affect Cabometyx include:
  • grapefruit
  • grapefruit juice

Cabometyx is approved to treat the following conditions.

• Advanced renal cell carcinoma (RCC). Doctors can prescribe Cabometyx to treat advanced RCC in adults. RCC is the most common type of kidney cancer.
• Advanced RCC in combination with another drug. Doctors can prescribe Cabometyx to treat advanced RCC in adults in combination with the drug nivolumab (Opdivo). Nivolumab also treats kidney cancer. Doctors may prescribe these medications together as a first treatment option for RCC.
• Hepatocellular carcinoma (HCC). Doctors can prescribe Cabometyx to treat HCC in adults. HCC is a type of liver cancer. The drug is used in people who have taken sorafenib (Nexavar) in the past for treating HCC.
• Advanced or metastatic differentiated thyroid cancer (DTC). Doctors can prescribe Cabometyx to treat DTC that is advanced or metastatic. (Metastatic means the cancer has spread to other parts of the body.) Cabometyx can be prescribed for DTC in certain adults and children if certain other treatments weren’t effective in treating their DTC or cannot be used.

Cancer can happen when your cells grow abnormally or very quickly. This can cause tumors, which can spread throughout your body if untreated.

Cabometyx works by blocking a protein in your body called tyrosine kinase. Tyrosine kinase is important in helping cancer cells thrive and grow in your body. Blocking tyrosine kinase helps stop the cancer cells from growing or spreading.

Cabometyx will begin working as soon as you take your first dose. However, it may take time to notice changes in tumor growth. Your doctor can check this growth using certain tests. They’ll use the test results to see whether the medication is working to stop your cancer from growing.

You may not notice Cabometyx working. However, still be sure to take your dose every day. Talk with your doctor about what to expect from treatment with Cabometyx.

Like other medications, prices for Cabometyx may vary. The drug’s price will depend on factors such as:

• the pharmacy you use
• your insurance coverage

Here’s a list of things to consider when looking into the cost of Cabometyx.

• Option for a 90-day supply. For some drugs, it’s possible to get a 90-day supply. If this option is approved by your insurance company, it can help lower the cost of the drug. It can also help you avoid frequent trips to your pharmacy. If you’d like to learn more about this option, ask your doctor, pharmacist, or insurance company.
• Need for prior authorization. Before insurance coverage for Cabometyx is approved, your insurance company may require prior authorization. In this case, your doctor and insurance company will communicate about your prescription for Cabometyx. Then, the insurance company will decide if the drug will be covered. To find out if you need prior authorization for Cabometyx, contact your insurance company.
• Possible cost assistance options. Financial assistance to help lower the cost of Cabometyx is available. The Exelixis Access Services program for Cabometyx may help reduce its cost. To learn more and find out if you’re eligible for support, call 844-900-EASE (844-900-3273). Or visit the manufacturer’s website. Also, check out this article to learn about ways to save on prescription drugs.
• Use of a specialty pharmacy. Cabometyx is only dispensed from specialty pharmacies. These pharmacies are authorized to handle certain drugs considered specialty medications. These medications may be expensive or require help from healthcare professionals to be used safely and effectively. Ask your doctor which specialty pharmacy they’ll prescribe Cabometyx through.
• Use of a mail-order pharmacy. Cabometyx may be dispensed through mail-order pharmacies. Getting your prescription through a mail-order pharmacy could lower its cost. It can also allow you to get the drug without leaving home. To find out more about this option, check with your doctor, pharmacist, or insurance company.
• Availability of a generic form. Cabometyx doesn’t come in a generic form. A generic drug is an exact copy of the active drug in a brand-name medication. Typically, generics cost less than brand-name drugs.

Your doctor will recommend how you should take Cabometyx. It’s important that you take the drug exactly as your doctor instructs.

Cabometyx comes as an oral tablet. You’ll take the tablets by swallowing them.

Here’s a list of common questions related to taking Cabometyx.

• When should I take Cabometyx? Take your dose of Cabometyx once each day. Try to take the medication around the same time each day. Taking Cabometyx around the same time of day helps keep a steady level of it in your body. This helps the medication work effectively. Try these tips to help avoid missing doses of Cabometyx. You could also set an alarm, use a timer, or download a reminder app on your phone.
• Do I need to take Cabometyx with food? No, you should not take Cabometyx with food. In fact, you should take this drug on an empty stomach. Take your dose at least 1 hour before you eat or 2 hours after you eat.
• Can Cabometyx be chewed, split, or crushed? No, you should not chew, split, or crush Cabometyx. This medication should be swallowed whole. If you’re having trouble swallowing Cabometyx tablets, talk with your doctor.
• Is there a best time of day to take Cabometyx? No, there’s not a best time of day to take Cabometyx. However, you should take your dose at around the same time each day. This helps you have a steady level of medication in your body. In addition, you should take Cabometyx 1 hour before you eat or 2 hours after you eat. So as long as you follow your doctor’s dosage instructions, you can take Cabometyx at whatever time is convenient for you.

Cabometyx should not be taken during pregnancy. This medication may cause harm to a developing fetus if taken during pregnancy.

This drug has not been clinically studied in pregnant people. However, based on how the medication works and animal studies, it’s not recommended during pregnancy.

In animal studies, this medication increased the risk of congenital anomalies (commonly known as birth defects) and pregnancy loss. However, animal studies do not always indicate what may happen in humans.

Due to this possible risk, doctors will recommend that people who can become pregnant take a pregnancy test before starting Cabometyx. If you’re able to become pregnant, your doctor will advise that you use birth control during and for a time after Cabometyx treatment. See the “Cabometyx: Birth control needs” section below to learn more.

If you’re pregnant or planning to become pregnant, talk with your doctor before taking Cabometyx.

It’s possible that Cabometyx may cause fertility problems. (Fertility describes the ability to become pregnant or cause pregnancy to occur.)

These risks have not been seen in humans. However, animal studies show that fertility may be affected by Cabometyx.

In animal studies, male rats given the drug had a decreased sperm count. Female rats given Cabometyx had increased rates of pregnancy loss.

However, it’s important to note that animal studies do not always indicate what may happen in humans. If you have concerns about your fertility while taking Cabometyx, talk with your doctor.

It’s likely not safe to take Cabometyx during pregnancy.

Talk with your doctor about your birth control needs with Cabometyx if you’re sexually active and you or your partner can become pregnant. Your doctor will advise that you use birth control with this medication.

If you’d like to learn more about taking Cabometyx during pregnancy, see the “Cabometyx: Taking while pregnant” section above.

Females* who can become pregnant will take a pregnancy test before starting treatment with Cabometyx. Then, their doctor will recommend using an effective form of birth control during treatment with this drug. Doctors will also advise that females continue using birth control for at least 4 months after their last dose of Cabometyx.

The manufacturer of Cabometyx doesn’t make any recommendations on birth control for males* using Cabometyx. If you are a male taking this medication, talk with your doctor if you have questions about birth control.

* Sex and gender exist on spectrums. Use of the terms “male” and “female” in this article refers to sex assigned at birth.

It’s not known whether it is safe to take Cabometyx while breastfeeding. It’s also unclear whether the drug is present in breast milk or what effects it may have on a child who is breastfed.

Due to the possible serious risks, doctors will advise that you do not breastfeed while taking Cabometyx. Your doctor will also recommend that you do not breastfeed for 4 months after stopping treatment with the drug.

If you are breastfeeding, talk with your doctor before starting treatment with Cabometyx.

Tell your doctor about your health history before starting treatment with Cabometyx. Your doctor may not recommend this medication if you have certain factors affecting your health or specific medical conditions.

These factors and conditions include those listed below.

• Liver problems other than liver cancer. If you have liver problems besides liver cancer, tell your doctor before starting treatment with Cabometyx. (Keep in mind that Cabometyx is used to treat a certain type of liver cancer.) This medication may cause liver problems. If you already have liver problems, Cabometyx may make your condition worse. Talk with your doctor about whether it’s safe for you to take Cabometyx.
• Bleeding. Tell your doctor if you have experienced bleeding recently, such as coughing or vomiting up blood. Your doctor will tell you whether it is safe for you to take Cabometyx.
• An open wound or wound that’s healing. Cabometyx may impair your body’s ability to heal wounds. If you have an open wound or a wound that is healing, your doctor will likely recommend that you start taking Cabometyx after your wound has healed.
• High blood pressure. Cabometyx may increase your blood pressure. If you already have high blood pressure, this medication may make your blood pressure worse. Your doctor will likely recommend managing your blood pressure with medications before taking Cabometyx.
• Low blood calcium level. Cabometyx may decrease your calcium level. If you already have a low calcium level, this medication may make your condition worse. In this case, your doctor will likely recommend treating the low calcium level before starting Cabometyx.
• Upcoming surgery or dental procedure. You should stop taking Cabometyx at least 3 weeks before having surgery. And you should not restart this medication until at least 2 weeks after your surgery. This is because Cabometyx may impair your body’s ability to heal wounds. Do not stop treatment with Cabometyx without first talking with your doctor. if you have an upcoming surgery or dental procedure, tell your doctor so that they can determine a treatment plan for you.
• Allergic reaction. Your doctor will likely not prescribe Cabometyx if you’ve had an allergic reaction to it or any of its ingredients. To find out about other treatment options, talk with your doctor.
• Pregnancy. You should not take Cabometyx during pregnancy. If you’d like to learn more information about taking Cabometyx while pregnant, view the “Cabometyx: Taking while pregnant” section above.
• Breastfeeding. You should not take Cabometyx while you’re breastfeeding. If you’d like to learn more information about taking Cabometyx while breastfeeding, view the “Cabometyx: Taking while breastfeeding” section above.

To learn more about effects of Cabometyx that could be harmful, see the “Cabometyx: Side effects” section above.

Serious effects can occur if you use more than the recommended dosage of Cabometyx. Do not use more Cabometyx than your doctor recommends.  

Symptoms that an overdose could cause include:

• memory problems
• weight loss
• kidney problems
• confusion

Call your doctor if you think you’ve taken too much of this drug. Also, you can call the American Association of Poison Control Centers at 800-222-1222 or use their online tool. However, if your symptoms are severe, call 911 or your local emergency number. Or go to the nearest emergency room right away.

Here’s some information about Cabometyx’s expiration date, as well as how to store and dispose of the drug.

• Expiration. Your pharmacist will add an expiration date to the label on Cabometyx’s bottle. This date is usually 1 year from the date the medication was dispensed to you. Expiration dates help ensure that a medication is effective during a period of time. The Food and Drug Administration (FDA) advises Trusted Source Food and Drug Administration (FDA) Governmental authority Go to source that you avoid using expired drugs. If you have an unused medication and it’s past the drug’s expiration date, talk with your pharmacist. They can let you know whether you might still be able to use the medication.
• Storage. Many factors determine how long a medication remains good to use. These factors include how and where you store the drug. Cabometyx tablets should be stored at room temperature, between 20°C and 25°C (68°F and 77°F). If necessary, you can store this medication between 15°C and 30°C (59°F and 86°F).
• Disposal. It’s important to safely dispose of Cabometyx if you no longer need to take it and have unused medication. Doing so helps prevent others, including children and pets, from accidentally taking the drug. It also helps avoid causing harm to the environment. Ask your pharmacist for information about disposing of Cabometyx. Also, check out this page for several tips on safe medication disposal.

If you have questions about Cabometyx, talk with your doctor. They can help advise you on whether Cabometyx could be a good treatment option for you.

Here’s a list of questions you may want to ask your doctor:

• How can I treat side effects I may experience with Cabometyx?
• What should I do if I become pregnant while I’m taking Cabometyx?
• Can you change my dose of Cabometyx if I have side effects from the drug?
• Do other medications I take increase my risk of side effects from Cabometyx?

Your doctor may also tell you about other treatment options for your condition. You may find these articles helpful in learning about alternative drugs for kidney cancer and liver cancer. And view our selection of videos on cancer treatment.

Disclaimer: Healthgrades has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.