What is angioedema? Angioedema is a localized tissue swelling similar to hives in which areas of raised, itchy skin appear. However, in contrast to hives, which appear on the surface of the skin, angioedema affects deeper layers of the skin and other organs (mouth, airways, intestinal tract, etc.). Angioedema may occur anywhere, but most commonly affects the skin around the eyes and around and in the mouth. Angioedema is generally a result of an allergic reaction, such as those due to food or medication allergies. Rarely, it can be hereditary. Angioedema may develop after an infection or in association with a chronic disease such as lupus or certain cancers. Since it is typically due to an allergic reaction, anyone can experience angioedema. The severity of angioedema is variable. Mild cases may not require medical treatment, but severe cases can lead to life-threatening consequences such as difficulty breathing. Treatments for angioedema can include steroids, antihistamines, epinephrine and other medications. In life-threatening cases, respiratory support, such as a breathing machine, may be necessary. In milder cases that do not compromise breathing, angioedema is not usually a serious condition and resolves on its own within a few days. While generally not a serious condition, angioedema can sometimes be life threatening. Seek immediate medical care (call 911) if angioedema becomes severe and begins to cause swelling in the area of your throat or mouth or you experience dizziness or fainting, difficulty swallowing, difficulty breathing, or if you experience chest pain or pressure. If you experience persistent angioedema (more than several days), are in pain, or your angioedema causes you concern, seek prompt medical care.